Vertical inline pump is a single-stage single-suction centrifugal pump with a bent pipe before the impeller, which is usually used where installation space is a constraint. In this paper, with three objective functions of efficiencies at 0.5 Qd, 1.0 Qd, and 1.5 Qd, a multi-objective optimization on the inlet pipe of a vertical inline pump was proposed based on genetic algorithm with artificial neural network (ANN). In order to describe the shape of inlet pipe, the fifth-order and third-order Bezier curves were adopted to fit the mid curve and the trend of parameters of cross sections, respectively. Considering the real installation and computation complexity, 11 variables were finally used in this optimization. Latin hypercube sampling (LHS) was adopted to generate 149 sample cases, which were solved by CFD code ANSYS cfx 18.0. The calculation results and design variables were utilized to train ANNs, and these surrogate models were solved for the optimum design using multi-objective genetic algorithm (MOGA). The results showed the following: (1) There was a great agreement between numerical results and experimental results; (2) The ANNs could accurately fit the objective functions and variables. The maximum deviations of efficiencies at 0.5 Qd, 1.0 Qd, and 1.5 Qd, between predicted values and computational values, were 1.94%, 2.35%, and 0.40%; (3) The shape of inlet pipe has great influence on the efficiency at part-load and design conditions while the influence is slight at overload condition; (4) Three optimized cases were selected and the maximum increase of the efficiency at 0.5 Qd, 1.0 Qd, and 1.5 Qd was 4.96%, 2.45, and 0.79%, respectively; and (5) The velocity distributions of outflow in the inlet pipe of the three optimized cases were more uniform than the original one.

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