The parameters affecting the onset of flashing in microjets were studied. A custom atomizer assembly was designed to produce jets of propellant mixtures at different temperatures. Propellants chosen were HFA134a and HFA227ea, which are used in most pressurized metered dose inhalers (pMDIs). Ethanol was added to the propellants to investigate its effect on flashing. Orifices used ranged from 5 to 35 μm in diameter. A critical jet diameter above which flashing was the dominant mechanism of atomization was found at each temperature and formulation. A correlation was developed to relate the critical jet diameter to the thermophysical properties of the formulation.

References

1.
Hochrainer
,
D.
,
Hölz
,
H.
,
Kreher
,
C.
,
Scaffidi
,
L.
,
Spallek
,
M.
, and
Wachtel.
,
H.
,
2005
, “
Comparison of the Aerosol Velocity and Spray Duration of Respimat Soft Mist Inhaler and Pressurized Metered Dose Inhalers
,”
J. Aerosol Med.
,
18
(
3
), pp.
273
282
.10.1089/jam.2005.18.273
2.
Lewis
,
D.
,
2007
, “
Metered-Dose Inhalers: Actuators Old and New
,”
Expert Opin. Drug Delivery
,
4
(
3
), pp.
235
245
.10.1517/17425247.4.3.235
3.
Clark
,
A. R.
,
1996
, “
MDIs: Physics of Aerosol Formation
,”
J. Aerosol Med.
,
9
(
Suppl 1
), pp.
S19
S26
.10.1089/jam.1996.9.Suppl_1.S-19
4.
Dunbar
,
C. A.
,
Watkins
,
A. P.
, and
Miller
,
J. F.
,
1997
, “
An Experimental Investigation of the Spray Issued From a pMDI Using Laser Diagnostic Techniques
,”
J. Aerosol Med.
,
10
(
4
), pp.
351
368
.10.1089/jam.1997.10.351
5.
Carey
,
V. P.
,
1992
, “
Liquid-Vapor Phase-Change Phenomena: An Introduction to the Thermophysics of Vaporization and Condensation Processes in Heat Transfer Equipment
,
Hemisphere
,
Washington, DC
.
6.
Clark
,
A. R.
,
1991
, “
Metered Atomisation for Respiratory Drug Delivery
,” Ph.D., thesis, Loughborough University, Loughborough, UK.
7.
Hickey
,
A. J.
,
2014
, “
Controlled Delivery of Inhaled Therapeutic Agents
,”
J. Controlled Release
,
190
, pp.
182
188
.10.1016/j.jconrel.2014.05.058
8.
Dunbar
,
C. A.
,
1997
, “
Atomization Mechanisms of the Pressurized Metered Dose Inhaler
,”
Part. Sci. Technol.
,
15
(
3
), pp.
195
216
.10.1080/02726359708906771
9.
Clark.
,
A. R.
,
1992
, “
The Physics of Aerosol Formation by MDIs—Limitations of the Current Approach
,”
J. Biopharm. Sci.
,
3
(
1
): pp.
69
76
.
10.
Finlay
,
W. H.
,
2001
,
The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction
,
Academic Press
,
San Diego, CA
, p.
306
.
11.
Versteeg
,
H. K.
,
Hargrave
,
G. K.
, and
Kirby
,
M.
,
2006
, “
Internal Flow and Near-Orifice Spray Visualisations of a Model Pharmaceutical Pressurised Metered Dose Inhaler
,”
Second International Conference on Optical and Laser Diagnostics
, 2006, Vol.
45
, pp.
207
213
.
12.
Shepherd
,
J. E.
, and
Sturtevant
,
B.
,
1982
, “
Rapid Evaporation at the Superheat Limit
,”
J. Fluid Mech.
,
121
, pp.
379
402
.10.1017/S0022112082001955
13.
Park
,
H. C.
,
Byun
,
K. T.
, and
Kwak
,
H. Y.
,
2005
, “
Explosive Boiling of Liquid Droplets at Their Superheat Limits
,”
Chem. Eng. Sci.
,
60
(
7
), pp.
1809
1821
.10.1016/j.ces.2004.11.010
14.
Shusser
,
M.
, and
Weihs
,
D.
,
1999
, “
Explosive Boiling of a Liquid Droplet
,”
Int. J. Multiphase Flow
,
25
(
8
), pp.
1561
1573
.10.1016/S0301-9322(98)00078-0
15.
Shusser
,
M.
, and
Weihs
,
D.
,
2001
, “
Stability of Rapidly Evaporating Droplets and Liquid Shells
,”
Int. J. Multiphase Flow
,
27
(
2
), pp.
299
345
.10.1016/S0301-9322(00)00017-3
16.
Kolev
,
N. I.
,
2011
,
Multiphase Flow Dynamics
. 4th ed.,
Springer
,
Berlin
, pp.
2
3
.
17.
Razzaghi
,
M.
,
1989
, “
Droplet Size Estimation of 2-Phase Flashing Jets
,”
Nucl. Eng. Des.
,
114
(
1
), pp.
115
124
.10.1016/0029-5493(89)90130-1
18.
Lienhard
,
J. H.
, and
Day
,
J. B.
,
1970
, “
The Breakup of Superheated Liquid Jets
,”
ASME J. Fluids Eng.
,
92
(
3
), pp.
515
521
.10.1115/1.3425051
19.
Kitamura
,
Y.
,
Morimitsu
,
H.
, and
Takahashi
,
T.
,
1986
, “
Critical Superheat for Flashing of Superheated Liquid Jets
,”
Ind. Eng. Chem. Fundam.
,
25
(
2
), pp.
206
211
.10.1021/i100022a005
20.
Brown
,
R.
, and
York
,
J. L.
,
1962
, “
Sprays Formed by Flashing Liquid Jets
,”
AIChE J.
,
8
(
2
), pp.
149
153
.10.1002/aic.690080204
21.
Zeigerson-Katz
,
M.
, and
Sher
,
E.
,
1998
, “
Spray Formation by Flashing of a Binary Mixture: A Parametric Study
,”
Atomization Sprays
,
8
(
3
), pp.
255
266
.10.1615/AtomizSpr.v8.i3.20
22.
Reitz
,
R. D.
,
1990
, “
A Photographic Study of Flash-Boiling Atomization
,”
Aerosol Sci. Technol.
,
12
(
3
), pp.
561
569
.10.1080/02786829008959370
23.
Zhou
,
Z. F.
,
Weitao
,
W.
,
Bin
,
C.
,
Guoxiang
,
W.
, and
Liejin
,
G.
,
2012
, “
An Experimental Study on the Spray and Thermal Characteristics of R134a Two-Phase Flashing Spray
,”
Int. J. Heat Mass Transfer
,
55
(
15–16
), pp.
4460
4468
.10.1016/j.ijheatmasstransfer.2012.04.021
24.
Zhou
,
Z.-F.
,
Wu
,
W.-T.
,
Chen
,
B.
,
Guo
,
L.-J.
, and
Wang
,
Y.-S.
,
2011
, “
Visualization and Characterization of the Flashing Spray of Cryogen R404a
,”
ASME
Paper No. IMECE2011-6503710.1115/IMECE2011-65037.
25.
Brennen
,
C. E.
,
1995
,
Cavitation and Bubble Dynamics
(Oxford Engineering Science Series),
Oxford University Press
,
New York
, p.
282
.
27.
Tamaki
,
N.
,
Shimizu
,
M.
,
Nishida
,
K.
, and
Hiroyasu
,
H.
,
1998
, “
Effects of Cavitation and Internal Flow on Atomization of a Liquid Jet
,”
Atomization Sprays
,
8
(
2
), pp.
179
197
.10.1615/AtomizSpr.v8.i2.30
28.
Kundu
,
P. K.
,
Cohen
,
I. M.
, and
Dowling
,
D. R.
,
2012
,
Fluid Mechanics
, 5th ed., Vol.
xxvi
,
Academic Press
,
Waltham, MA
, p.
891
.
29.
Ivey
,
J. W.
,
Lewis
,
D.
,
Church
,
T.
,
Finlay
,
W. H.
, and
Vehring
,
R.
,
2014
, “
A Correlation Equation for the Mass Median Aerodynamic Diameter of the Aerosol Emitted by Solution Metered Dose Inhalers
,”
Int. J. Pharm.
,
465
(
1–2
), pp.
18
24
.10.1016/j.ijpharm.2014.01.039
30.
Sher
,
E.
,
Bar-Kohany
,
T.
, and
Rashkovan
,
A.
,
2008
, “
Flash-Boiling Atomization
,”
Prog. Energy Combust. Sci.
,
34
(
4
), pp.
417
439
.10.1016/j.pecs.2007.05.001
31.
Smyth
,
H. D.
,
Mejia-Millan
,
E. A.
, and
Hickey
,
A. J.
,
2002
, “
The Effect of Ethanol on Solvency, Vapor Pressure, and Emitted Droplet Size of Solution Metered Dose Inhalers Containing HFA 134a
,”
Respiratory Drug Delivery VIII
,
2002
, pp.
735
738
.
32.
Mutair
,
S.
, and
Ikegami
,
Y.
,
2012
, “
On the Evaporation of Superheated Water Drops Formed by Flashing of Liquid Jets
,”
Int. J. Therm. Sci.
,
57
, pp.
37
44
.10.1016/j.ijthermalsci.2011.10.013
33.
Yaws
,
C. L.
,
2014
, “
Yaws' Critical Property Data for Chemical Engineers and Chemists, Knovel
,” http://app.knovel.com/hotlink/toc/id:kpYCPDCECD/yaws-critical-property/yaws-critical-property
34.
Mexichem UK Limited
,
2010
,
ZEPHEX® 134a: Physical Property Data Sheet SI Units
,
Runcorn
,
UK
.
35.
Mexichem UK Limited
,
2010
,
ZEPHEX® 227ea: Physical Property Data Sheet SI Units
,
Runcorn
,
UK
.
36.
Yaws
,
C. L.
,
2003
, “
Yaws' Handbook of Thermodynamic and Physical Properties of Chemical Compounds, Knovel
,” http://app.knovel.com/hotlink/toc/id:kpYHTPPCC4/yaws-handbook-thermodynamic/yaws-handbook-thermodynamic
37.
Design Institute for Physical Properties
,
S.b.A., DIPPR Project 801: Full Version
,
Design Institute for Physical Property Research/AIChE
.
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