Microfluidic sensors have been very effective for rapid, portable bioanalysis, such as in determining the pH of a sample. By simultaneously detecting multiple chemicals, the overall measurement performance can be greatly improved. One such method involves a series of parallel microchannels, each of which measures one individual agent. For unbiased readings, the flow rate in each channel should be approximately the same. In addition, the system needs a compact volume which reduces both the wasted channel space and the overall device cost. To achieve these conditions, a manifold was designed using a tapered power law, based on a concept derived for electronics cooling systems. This manifold features a single feed passage of varying diameter, eliminating the excess volume from multiple branch steps. The design was simulated using computational fluid dynamics (CFD), which demonstrated uniform flow performance within 2.5% standard deviation. The design was further examined with microparticle image velocimetry (PIV), and the experimental flow rates were also uniform with approximately 10% standard deviation. Hence, the tapered power law can provide a uniform flow distribution in a compact package, as is needed in both this microfluidic sensor and in electronics cooling applications.
Uniform Flow Control for a Multipassage Microfluidic Sensor
Department of Mechanical Engineering,
Manuscript received April 13, 2012; final manuscript received November 26, 2012; published online March 19, 2013. Assoc. Editor: Kendra Sharp.
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Solovitz, S. A., Zhao, J., Xue, W., and Xu, J. (March 19, 2013). "Uniform Flow Control for a Multipassage Microfluidic Sensor." ASME. J. Fluids Eng. February 2013; 135(2): 021101. https://doi.org/10.1115/1.4023444
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