We present a novel separation device for the front-end of a biodetection system to discriminate between biological and non-biological analytes captured in air samples. By combining AC dielectrophoresis along the flow streamlines and a field-induced phase-separation, the device utilizes “dielectrophoretic gating”to separate analytes suspended in a flowing fluid based on their intrinsic polarizability properties. The gates are integrated into batch fabricated self-sealed surface-micromachined fluid channels. We demonstrate that setting the gate to a moderate voltage in the radio frequency range removed bacteria cells from a mixture containing non-biological particles without the need for fluorescent labeling or antibody-antigen hybridization, and also validate experimentally basic relations for estimating the gate performance.
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e-mail: dawnb@umbc.edu
e-mail: khusid@adm.njit.edu
e-mail: acrivos@scisun.sci.ccny.cuny.edu
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January 2006
Special Section On The Fluid Mechanics And Rheology Of Nonlinear Materials At The Macro, Micro And Nano Scale
Surface Micromachined Dielectrophoretic Gates for the Front-End Device of a Biodetection System
Dawn Bennett,
e-mail: dawnb@umbc.edu
Dawn Bennett
The University of Maryland
, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250
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Boris Khusid,
Boris Khusid
New Jersey Institute of Technology,
e-mail: khusid@adm.njit.edu
University Heights
, Newark, NJ 07102
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Andreas Acrivos
Andreas Acrivos
The Levich Institute,
e-mail: acrivos@scisun.sci.ccny.cuny.edu
The City College of New York
, 140th Street & Convent Avenue, New York, NY 10031
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Conrad D. James
Murat Okandan
Paul Galambos
Seethambal S. Mani
Dawn Bennett
The University of Maryland
, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250e-mail: dawnb@umbc.edu
Boris Khusid
New Jersey Institute of Technology,
University Heights
, Newark, NJ 07102e-mail: khusid@adm.njit.edu
Andreas Acrivos
The Levich Institute,
The City College of New York
, 140th Street & Convent Avenue, New York, NY 10031e-mail: acrivos@scisun.sci.ccny.cuny.edu
J. Fluids Eng. Jan 2006, 128(1): 14-19 (6 pages)
Published Online: April 21, 2005
Article history
Received:
July 20, 2004
Revised:
April 21, 2005
Citation
James, C. D., Okandan, M., Galambos, P., Mani, S. S., Bennett, D., Khusid, B., and Acrivos, A. (April 21, 2005). "Surface Micromachined Dielectrophoretic Gates for the Front-End Device of a Biodetection System." ASME. J. Fluids Eng. January 2006; 128(1): 14–19. https://doi.org/10.1115/1.2136924
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