Aeroderivative gas turbines have their combustion set points adjusted periodically in a process known as remapping. Even turbines that perform well after remapping may produce unacceptable behavior when external conditions change. This article introduces a digital twin that uses real-time measurements of combustor acoustics and emissions in a machine learning model that tracks recent operating conditions. The digital twin is leveraged by an optimizer that select adjustments that allow the unit to maintain combustor dynamics and emissions in compliance without seasonal remapping. Results from a pilot site demonstrate that the proposed approach can allow a GE LM6000PD unit to operate for ten months without seasonal remapping while adjusting to changes in ambient temperature (4 − 38 °C) and to different fuel compositions.