Despite significant progress in the development of circulatory-assist devices over the last several decades, one of the major requirements for current clinical and pre-clinically tested devices remains the reduction of mechanical blood trauma. This blood trauma is associated with known complications of mechanically assisted circulation, such as thrombosis, coagulopathy, postoperative bleeding, increased susceptibility to inflammation and infection, compromised microcirculation and neurological injury, which is especially important in pediatric patients. Despite numerous experimental and computational studies of blood trauma conducted over several decades by investigators worldwide, there are still no reliable widely-accepted algorithms to minimize blood trauma at the circulatory-assist device...