This chapter focuses on generating optimized topologies using multiple materials. The interest in multi-material topology optimization (MMTO) stems from the well-recognized synergy between topology optimization (TO) and additive manufacturing (AM), where organic structures created through TO can be directly fabricated by a variety of AM processes. Given the rapidly increasing capabilities of AM, there is an opportunity to improve the performance of consumer products, biomedical, and aerospace components, through simultaneous optimization of topology and distribution of multiple materials.