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Proceedings of the 10th International Symposium on Cavitation (CAV2018)

Editor
Joseph Katz
Joseph Katz
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ISBN:
9780791861851
No. of Pages:
1108
Publisher:
ASME Press
Publication date:
2018

Ultrasound-induced cavitation microbubbles can lead to cell injury or mechanotransduction via calcium signaling processes such as intracellular calcium waves (ICWs). However, the mechanisms by which microbubbles stimulate ICWs remain unknown. Using a microfluidic platform with highly controlled bubble-cell interaction, we have identified two distinct types of ICWs – a fast response correlating with significant membrane poration, and a slow response triggered by calcium influx through stretch-activated ion channels. The fast ICWs, distinguished from those under physiological conditions, are associated with cell injuries. We further elicited ICWs without cell injury by displacing integrin-binding beads on the cell membrane under mild cavitation conditions. This study provides mechanistic insights into ICWs for guiding ultrasound therapy in tissue modification, drug delivery, and cell mechanotransduction.

Introduction
Body
Discussion and Conclusion
References
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