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BioNano Monographs

Impedimetric Biosensors for Medical Applications: Current Progress and Challenges

Editor
J. V. Rushworth
J. V. Rushworth
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N. A. Hirst
N. A. Hirst
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J. A. Goode
J. A. Goode
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D. J. Pike
D. J. Pike
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A. Ahmed
A. Ahmed
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P. A. Millner
P. A. Millner
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ISBN:
9780791860243
No. of Pages:
78
Publisher:
ASME Press
Publication date:
2013
Description

In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of the science and technology underpinning impedance-based biosensors is reviewed in detail. The layer-by-layer construction of impedimetric sensors is described, including the design of electrodes, their nano-modification, transducer surface functionalisation and the attachment of different bioreceptors. The current challenges of translating lab-based biosensor platforms into commercially-available devices that function with real patient samples at the POC are presented; this includes a consideration of systems integration, microfluidics and biosensor regeneration. The final section of this monograph describes case studies of successful impedance-based biosensors for the detection of a range of analytes from small molecules up to whole microorganisms. Finally, the authors put forward future perspectives for the clinical applications of impedimetric biosensors.

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