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BioNano Monographs
Nanoparticles and Brain Tumor Treatment
Editor
ISBN:
9780791860038
No. of Pages:
110
Publisher:
ASME Press
Publication date:
2012
eBook Chapter
2 Glioma Biology
Page Count:
5
-
Published:2012
Citation
Caruso, G, Caffo, M, Raudino, G, & Tomasello, F. "Glioma Biology." Nanoparticles and Brain Tumor Treatment. Ed. Caruso, G, Caffo, M, Raudino, G, & Tomasello, F. ASME Press, 2012.
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Genomic DNA aberrations are key genetic events in gliomagenesis. Recurrent genomic regions of alteration, including net gains and losses, have been found in gliomas. Whereas some of these regions contain known oncogenes and tumor suppressor genes, the biologically relevant genes within other regions remain to be identified. The phenotypic and genotypic heterogeneity indicate that no isolated genetic event accounts for gliomagenesis, but rather the cumulative effects of a number of alterations that operate in a concerted manner. In this pathological process are included various biological events, such as activation of growth factor receptor signaling pathways, down-regulation of many apoptotic mechanisms,...
2.1 Invasion and angiogenesis
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