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GFP Whole Cell Microbial Biosensors: Scale-up and Scale-down Effects on Biopharmaceutical Processes

BioNano Monographs

GFP Whole Cell Microbial Biosensors: Scale-up and Scale-down Effects on Biopharmaceutical Processes

Editor

ISBN:

9780791860090

No. of Pages:

60

DOI:

https://doi.org/10.1115/1.860090

Publisher:

ASME Press

Publication date:

2012

eBook Chapter

2 Interaction between fluid flow and microbial cells: importance of the operating scale

By

Frank Delvigne

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,

Alison Brognaux

Alison Brognaux

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,

Shanshan Han

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,

Søren J. Sørensen

Søren J. Sørensen

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,

Philippe Thonart

Philippe Thonart

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Doi:

https://doi.org/10.1115/1.860090_ch1

Page Count:

8

Published:

2012

Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters.

1.1 Different scales involved in the development of microbial bioprocesses

1.2 Hydrodynamic modeling of the substrate heterogeneites perceived by cells

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