GFP Whole Cell Microbial Biosensors: Scale-up and Scale-down Effects on Biopharmaceutical Processes
2 Interaction between fluid flow and microbial cells: importance of the operating scale
Download citation file:
Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters.