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Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling

Editor
Ahmed Al-Jumaily
Ahmed Al-Jumaily
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Azra Alizad
Azra Alizad
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ISBN-10:
0791802755
ISBN:
9780791802755
No. of Pages:
350
Publisher:
ASME Press
Publication date:
2008

This chapter describes the effects of ultrasound stimulation on chondrocytes in three-dimensional culture in relation to the production of regenerative cartilage tissue, using collagen sponges as a carrier and supplementation with hyaluronic acid (used in the conservative treatment of osteoarthritis), and the mechanism of the adaptive response of chondrocytes to mechanical loading. It has been shown that cell proliferation and matrix production can be facilitated by considering the mechanical environment of the cultured chondrocytes and the mechanical properties of the scaffold structure used in the culture and of the stimulation used. On the basis of these results, it may be...

Abstract
5.1 Introduction
5.2 Functional Adaptation of Articular Cartilage to Mechanical Loading
5.3 Use of Mechanical Stimulation for the Production of Regenerative Cartilage Tissue
5.4 Materials and Methods for the Investigation of the Effects of Ultrasound Stimulation on Chondrocytes in Three-Dimensional Culture
5.4.1 Cell Cultures
5.4.2 Experimental Setup
5.4.3 Experimental Methods
5.4.4 Statistical Analyses
5.5 Results and Discussions for the Investigation of the Effects of Ultrasound Stimulation on Chondrocytes in Three-Dimensional Culture
5.5.1 Cell Proliferation
5.5.2 Quantity Of Chondroitin Sulfates In Supernatants
5.5.3 Histologic Examination
5.5.4 Immunohistochemical Examination
5.5.5 Type II Collagen Gene Expression
5.6 Mechanism of Functional Adaptation of Chondrocytes to Mechanical Loading
5.7 Summary
References
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