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Biomedical Applications of Vibration and Acoustics in Imaging and Characterizations
Mostafa Fatim
Mostafa Fatim
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Ahmed Al-Jumaily
Ahmed Al-Jumaily
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ASME Press
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Quantitative measurement of tissue elasticity and viscosity has important medical applications because pathologies are often linked to abnormal tissue mechanical properties. Shearwave Dispersion Ultrasound Vibrometry (SDUV) is proposed to quantify tissue viscoelasticity. SDUV uses a focused ultrasound beam within FDA safety limits to stimulate formation and propagation of harmonic shear waves in the studied tissue. The propagation speed of induced shear wave is frequency-dependent (dispersive) and relates to the tissue's mechanical properties. Shear wave speeds at a number of frequencies are measured by pulse-echo ultrasound setup and fit with a theoretical dispersion model to inversely solve for tissue elasticity and viscosity. A special pulse sequence is developed to make SDUV compatible with commercial ultrasound scanners. In vitro SDUV measurements in gelatin phantom, liver, and pork and beef muscle show promising results, demonstrating the feasibility of SDUV to quantify tissue elasticity and viscosity.

12.1 Introduction
12.2 Principle of SDUV
12.3 Vibration Detection with Pulse-Echo Ultrasound
12.4 Motion Generation and Detection with a Single-Array Transducer
12.4.1 Motivation
12.4.2 Challenges
12.4.3 Intermittent Pulse Sequence
12.5 Discussion
12.6 Conclusions
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