International Conference on Computer Technology and Development, 3rd (ICCTD 2011)
195 Studies on the Ketoprofen- Polybutylcyanoacrylate-Nanoparticles of Zedoary Turmeric Oil
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Objective: To investigate the optimum preparation conditions of the Ketoprofen-Ploybutylcyanoacrylate- Nanoparticles of zedoary turmeric oil (ZTO-PBCA-NP). Methods: The optimization of preparation process of ZTO-PBCA-NP was studied with the butylcyanoacrylate (BCA) as the polymeric materials, with ebedding ration as the evaluation index and with uniform design optimization ZTO-PBCA-NP preparation. Results: The multiple regression equation by the uniform design optimization ZTO-PBCA-NP preparation was Y = 179.157+24.958A11Â182.328A21Â13.468A5 (R = 0.9254, F = 32.114, P<0.01), the average ebedding ratio was between 84.90% ÃÂ± 2.40% under optimum conditions. Conclusion: The Curcuma oil, BCA dosage and pH value are linear regression with the ebedding ratio of ZTO-PBCA-NP. The study screens out the optimum preparation conditions of ZTO-PBCA-NP.