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BioNano Monographs
Chitosan and Its Derivatives as Promising Drug Delivery Carriers
Editor
ISBN:
9780791860052
No. of Pages:
84
Publisher:
ASME Press
Publication date:
2012
eBook Chapter
4 Chitosan-Based Drug Delivery Systems
Page Count:
50
-
Published:2012
Crosslinking of biodegradable polymers is potentially important to control swelling and degradation rates. The earliest work in chitosan nanostructures predominantly involved chemical cross-linking reactions to the polymer chain. Watzke et al. formed chitosan-silica nanocomposites by reacting tetramethoxysilane to the hydroxyl groups on the chitosan monomer [48]. However, attempts were not made to associate active agents to the polymer network. Ohya et al. was the first to present data involving chitosan nanospheres for the drug 5-fluorouracil (5- FU) delivery applications, using a water-in-oil emulsion method followed by glutaraldehyde cross-linking of the chitosan amino groups [49]. Yao et al. have prepared an...
Topics:
Biodegradation,
Cell membranes,
Chain,
Coating processes,
Coatings,
Crystals,
Drug delivery systems,
Drugs,
Emulsions,
Evaporation,
Liquid crystals,
Nanocomposites,
Nanostructures ,
Phase transition temperature,
Phase transitions,
Physiology,
Polymer chains,
Polymers,
Surfactants,
Temperature,
Water
4.1 Chitosan microspheres
4.2 Chemically modified chitosan
4.3 Graft Copolymerized chitosan
4.4 Chitosan-based stimuli-responsive hydrogels
4.5 Chitosan-ligand conjugates for active target drug delivery
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