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BioNano Monographs
Chitosan and Its Derivatives as Promising Drug Delivery Carriers
Editor
M. Prabaharan
M. Prabaharan
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ISBN:
9780791860052
No. of Pages:
84
Publisher:
ASME Press
Publication date:
2012

Chitosan has been marketed throughout the world as a component in non-medical products, as an approved food additive, and as a fat binder in cholesterol-lowering and slimming formulations [14]. It has been claimed that chitosan entraps lipids in the intestine, because of its cationic nature [15]. It has also been studied in the biomedical field and has been found to be highly biocompatible [16]. It is found that chitosan is metabolized by certain human enzymes, especially lysozyme, and is considered biodegradable [17]. Chitosan has also been approved by the authorities, and a monograph relating to chitosan hydrochloride was included in the fourth edition of the European Pharmacopoeia (2002).

3.1 Biocompatibility and biodegradability
3.2 pH sensitivity
3.3 Controlled drug release properties
3.4 Mucoadhesive properties
3.5 Permeation enhancing properties
3.6 Transfection enhancing properties
3.7 Gelling properties
3.8 Colon targeting properties
3.9 Ease of chemical modification
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