This research investigates the characteristics of meso-scale end-milling process using compressed chilly air and MoS₂ nanofluid minimum quantity lubrication (MQL). For the process characterization, the meso-scale end-milling experiments are conducted in the miniaturized machine tool system, and machining force and surface roughness are measured and compared. The experimental results show that the use of compressed chilly air and nanofluid MQL is effective for improving surface finish and reducing machining force in the meso-scale end-milling process.