This article introduces the biology non- smoothness, which generally exists in the natural environments. The various superficial shape of the biological living organism, no matter it is on the land, in the sea, or in the air, often has the non- smooth surface, which has evolved for adapting to the different living conditions. The non-smooth surface has the characters of reducing resistance, anti-adherence, and anti-friction. These characteristics have been successfully applied to reduce resistance on airplane surface, reduce sticks on plough surface and wear the engine piston surface. The article also studied the bionic non- smooth drilling bit by applying the bionic non- smooth theory to the design of diamond bit, and the JBD-75S bionic non-smooth diamond bit was developed. Field trial proved that bionic bit was superior to conventional bit both in the drilling effectiveness and in lifetime.