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Intelligent Engineering Systems Through Artificial Neural Networks, Volume 17

Editor
C. H. Dagli
C. H. Dagli
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ISBN-10:
0791802655
No. of Pages:
650
Publisher:
ASME Press
Publication date:
2007

The structural alignment of proteins is very important because structure of a protein is more closely related to function than sequence and also makes clear the common ancestry of proteins. There have been a number of tools developed to study three-dimensional protein structure. Most of these tools are vector based or distance based and use the Euclidean distance measure. In this project we use fuzzy alignment measures, along with powerful pattern-matching heuristics, to understand the functional and structural similarities of proteins whose underlying amino acid sequences may be different. Our datasets are the protein structures available in the Protein Data Bank (PDB), represented by their PDB ids.

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