Due to the changing economic and regulatory conditions associated with commercial nuclear power generation, effective nuclear safety risk management will be a cornerstone for both the successful continued operation of existing nuclear power plants and the addition of new nuclear-fueled generating capacity. In this paper we describe an integrated framework in which the infusion of risk management into plant programs and processes will cost-effectively ensure this objective is met. This framework has been developed over several years. It includes theoretical modeling of the impact of plant programmatic performance on nuclear safety risk. Analysis of these models permitted identification of attributes...