A statistical treatment of a pharmacokinetic compartmental model is described, wherein the initial drug concentration and/or the rate constants governing the distribution of the drug between the appropriate compartments are considered to be random variables. A specific pharmacokinetic model which describes the profile of the antibiotic coumermycin A, following intravenous and oral administration in man, is stochastized and a numerical comparison between the deterministic and the mean of the random solutions as a function of time is presented.

This content is only available via PDF.
You do not currently have access to this content.