Mechanical insufflation-exsufflation (MI-E) secretion clearance system is usually utilized to help patients to clear secretion. In this paper, to obtain the essential dynamic characteristics of volume-controlled (VC) MI-E secretion clearance system with double lungs, a dimensionless model of the MI-E secretion clearance system is derived. Furthermore, for the validation of the mathematical model, a prototype VC MI-E secretion clearance system is proposed. Finally, to reveal the impact of key parameters on VC MI-E secretion clearance system, a dimensionless orthogonal experiment with four factors and five levels was processed. And then, coupling effects of two lungs on VC MI-E secretion clearance system were illustrated. This paper can be referred to in treatment of secretion clearance with VC secretion clearance system.

References

References
1.
Tehrani
,
F. T.
,
2013
, “
A Control System for Mechanical Ventilation of Passive and Active Subjects
,”
Comput. Methods Prog. Biomed.
,
110
(3), pp.
511
518
.
2.
Pilbeam
,
S. P.
, and
Cairo
,
J. M.
,
2006
,
Mechanical Ventilation: Physiological and Clinical Application
,
4th ed.
,
Mosby Elsevier
,
St. Louis, MO
.
3.
Chatburn
,
R. L.
,
2007
, “
Classification of Ventilator Modes, Update and Proposal for Implementation
,”
Respir. Care
,
52
(3), pp.
301
323
.http://rc.rcjournal.com/content/52/3/301
4.
Glynn
,
F.
, and
Fenton
,
J. E.
,
2008
, “
Diagnosis and Management of Supraglottitis (Epiglottitis)
,”
Curr. Infect. Dis. Rep.
,
10
, pp.
200
204
.
5.
Katori
,
H.
, and
Tsukuda
,
M.
,
2005
, “
Acute Epiglottitis: Analysis of Factors Associated With Airway Intervention
,”
J. Laryngol. Otol.
,
119
(12), pp.
967
972
.https://doi.org/10.1258/002221505775010823
6.
Guldfred
,
L. A.
,
Lyhne
,
D.
, and
Becker
,
B. C.
,
2008
, “
Acute Epiglottitis: Epidemiology, Clinical Presentation, Management and Outcome
,”
J. Laryngol. Otol.
,
122
(8), pp.
818
823
.https://doi.org/10.1017/S0022215107000473
7.
Wanner
,
A.
,
Salathé
,
M.
, and
O'Riordan
,
T. G.
,
1996
, “
Mucociliary Clearance in the Airways
,”
Am. J. Respir. Crit. Care Med.
,
154
(
6
), pp.
1868
1902
.
8.
Shi
,
Y.
,
Zhang
,
B.
,
Wang
,
Z.
,
Cai
,
M.
, and
Shen
,
D.
,
2016
, “
New Advances in Monitoring and Triggering of Mechanical Ventilation
,”
Sci. China, Ser. E
,
59
(
11
), pp.
1791
1792
.
9.
Rose
,
L.
, and
Hanlon
,
G.
,
2011
, “Ventilation and Oxygenation Management,”
ACCCN's Critical Care Nursing
,
Elsevier
,
Amsterdam, The Netherlands
, pp.
381
413
.
10.
Newmarch
,
C.
,
2006
, “
Caring for the Mechanically Ventilated Patient: Part Two
,”
Nurs. Stand.
,
20
(18), pp.
55
64
.
11.
Feltracco
,
P.
,
Falasco
,
G.
,
Barbieri
,
S.
,
Milevoj
,
M.
,
Serra
,
E.
, and
Ori
,
C.
,
2011
, “
Anesthetic Considerations for Nontransplant Procedures in Lung Transplant Patients
,”
J. Clin. Anesth.
,
23
(6), pp.
508
516
.
12.
Avinash
,
S.
, and
Carli
,
F.
,
2008
, “The Role of Regional Anaesthesia in Patient Outcome: Thoracic and Abdominal Surgeries,”
Techniques in Regional Anesthesia and Pain Management
,
Elsevier
,
Amsterdam, The Netherlands
, pp.
183
193
.
13.
Munnur
,
U.
,
Bandi
,
V. D.
, and
Gropper
,
M. A.
,
2009
, “
Airway Management and Mechanical Ventilation in Pregnancy
,” Pulmonary Problems in Pregnancy, Humana Press, New York, pp. 385–103.
14.
Shi
,
Y.
,
Li
,
F.
,
Cai
,
M.
, and
Yu
,
Q.
,
2016
, “
Literature Review: Present State and Future Trends of Air-Powered Vehicles
,”
J. Renewable Sustainable Energy
,
8
(
2
), p.
025704
.
15.
Tsoumakidou
,
M.
, and
Siafakas
,
N. M.
,
2006
, “
Novel Insights Into the Aetiology and Pathophysiology of Increased Airway Inflammation During COPD Exacerbations
,”
Respir. Res.
,
7
, p.
80
.https://doi.org/10.1186/1465-9921-7-80
16.
Morrissey
,
B. M.
,
2007
, “
Pathogenesis of Bronchiectasis
,”
Clin. Chest Med.
,
28
(2), pp.
289
296
.
17.
Huh
,
D.
,
Fujioka
,
H.
,
Tung
,
Y. C.
,
Futai
,
N.
,
Paine
,
R.
, III,
Grotberg
,
J. B.
, and
Takayama
,
S.
,
2007
, “
Acoustically Detectable Cellular-Level Lung Injury Induced by Fluid Mechanical Stresses in Microfluidic Airway Systems
,”
Proc. Natl. Acad. Sci. U. S. A.
,
104
(48), pp.
18886
18891
.
18.
Wang
,
J. M.
,
2013
, “
Preparation and Characterization of the Anti-Virus and Anti-Bacteria Composite Air Filter Materials
,”
Sci. China Technol. Sci.
,
56
(1), pp.
48
52
.
19.
Branson
,
R. D.
,
2007
, “
Secretion Management in the Mechanically Ventilated Patient
,”
Respir. Care
,
52
(10), pp.
1328
1347
.http://rc.rcjournal.com/content/52/10/1328/tab-article-info
20.
Safdar
,
N.
,
Crnich
,
C. J.
, and
Maki
,
D. G.
,
2005
, “
The Pathogenesis of Ventilator-Associated Pneumonia: Its Relevance to Developing Effective Strategies for Prevention
,”
Respir. Care
,
50
(6), pp.
725
741
.http://rc.rcjournal.com/content/50/6/725.short
21.
Yan
,
S.
,
Wu
,
T.
,
Cai
,
M.
,
Wang
,
Y.
, and
Xu
,
W.
,
2016
, “
Energy Conversion Characteristics of a Hydropneumatic Transformer in a Sustainable-Energy Vehicle
,”
Appl. Energy
,
171
, pp.
77
85
.
22.
Hess
,
D. R.
,
2005
, “
Patient Positioning and Ventilator-Associated Pneumonia
,”
Respir. Care
,
50
(7), pp.
892
899
.https://www.ncbi.nlm.nih.gov/pubmed/15972110
23.
Adam
,
G.
,
Polak
., and
Janusz
,
M.
,
2006
, “
Nonlinear Model for Mechanical Ventilation of Human Lungs
,”
Comput. Biol. Med.
,
36
(1), pp.
41
58
.https://doi.org/10.1016/j.compbiomed.2004.08.001
24.
Diong
,
B.
,
Goldman
,
M.
, and
Nazeran
,
H.
,
2010
, “
Respiratory Impedance Values in Adults Are Relatively Insensitive to Mead Model Lung Compliance and Chest Wall Compliance Parameters
,” 26th Southern Biomedical Engineering Conference (
SBEC
2010), College Park, MA, Apr. 30–May 2, pp.
201
203
.https://doi.org/10.1007/978-3-642-14998-6_51
25.
Shi
,
Y.
,
Niu
,
J.
,
Cao
,
Z.
,
Cai
,
M.
, and
Zhu
,
J.
,
2015
, “
Working Characteristics of a New Ventilator With Automatic Secretion Clearance Function
,”
Sci. China Technol. Sci.
,
58
(
6
), pp.
1046
1052
.
26.
Redlarski
,
G.
, and
Jaworski
,
J.
,
2013
, “
A New Approach to Modeling of Selected Human Respiratory System Diseases, Directed to Computer Simulations
,”
Comput. Biol. Med.
,
43
(
10
), pp.
1606
1613
.
27.
Shi
,
Y.
,
Ren
,
S.
,
Cai
,
M.
,
Xu
,
W.
, and
Deng
,
Q.
,
2014
, “
Pressure Dynamic Characteristics of Pressure Controlled Ventilation System of a Lung Simulator
,”
Comput. Math. Methods Med.
,
2014
, p.
761712
.http://dx.doi.org/10.1155/2014/761712
28.
Li
,
X. T.
,
Li
,
D. N.
, and
Dou
,
C. P.
,
2003
, “
An Algorithm for Calculating Fresh Air Age in Central Ventilation System
,”
Sci. China Technol. Sci.
,
46
(2), pp.
182
190
.
29.
Song
,
Y. Q.
,
Gao
,
B. E.
, and
Wang
,
X. W.
,
1998
, “
Semiviscosity Flow Equation With Variable Parameters Under Superplastic Tension Conditions
,”
Sci. China Technol. Sci.
,
41
(3), pp.
242
246
.https://doi.org/10.1007/BF02919434
30.
Song
,
Y. Q.
,
Cheng
,
Y. C.
, and
Wang
,
X. W.
,
1998
, “
A Mechanical Analysis of the Constitutive Parameters in the Semiviscosity Flow Equations Under the Superplastic Tension Conditions
,”
Sci. China Technol. Sci.
,
41
(
1
), pp.
37
44
.https://doi.org/10.1007/BF02916870
31.
Shi
,
Y.
,
Wang
,
Y.
,
Cai
,
M.
,
Zhang
,
B.
, and
Zhu
,
J.
,
2017
, “
Study on the Aviation Oxygen Supply System Based on a Mechanical Ventilation Model
,”
China J. Aeronaut.
, in press.
32.
Niu
,
J.
,
Shi
,
Y.
,
Cai
,
M.
,
Cao
,
Z.
,
Wang
,
D.
,
Zhang
,
Z.
, and
Zhang
,
D. X.
,
2017
, “
Detection of Sputum by Interpreting the Time-Frequency Distribution of Respiratory Sound Signal Using Image Processing Techniques
,”
Bioinformatics
, in press.
33.
Niu
,
J. L.
,
Yan
,
S.
,
Cao
,
Z. X.
,
Cai
,
M. L.
,
Wei
,
C.
,
Jian
,
Z.
, et al. .,
2017
, “
Study on Air Flow Dynamic Characteristic of Mechanical Ventilation of a Lung Simulator
,”
Sci. China Technol. Sci.
,
60
(
2
), pp.
243
250
.
34.
Ren
,
S.
,
Shi
,
Y.
,
Cai
,
M.
, and
Xu
,
W.
,
2017
, “
Influence of Secretion on Airflow Dynamics of Mechanical Ventilated Respiratory System
,”
IEEE/ACM Trans. Comput. Biol. Bioinf.
,
PP
(99), p.
1
.
35.
Ren
,
S.
,
Cai
,
M.
,
Shi
,
Y.
,
Xu
,
W.
, and
Zhang
,
X. D.
,
2017
, “
Influence of Bronchial Diameter Change on the Airflow Dynamics Based on a Pressure-Controlled Ventilation System
,”
Int. J. Numer. Methods Biomed. Eng.
, epub.
36.
Shi
,
Y.
,
Zhang
,
B.
,
Cai
,
M.
, and
Xu
,
W.
,
2017
, “
Coupling Effect of Double Lungs on a VCV Ventilator With Automatic Secretion Clearance Function
,”
IEEE/ACM Trans. Comput. Biol. Bioinf.
,
PP
(99), p.
1
.
37.
Shi
,
Y.
,
Zhang
,
B.
,
Cai
,
M.
, and
Zhang
,
D.
,
2016
, “
Numerical Simulation of Volume-Controlled Mechanical Ventilated Respiratory System With Two Different Lungs
,”
Int. J. Numer. Methods Biomed. Eng.
,
33
(9), p.
e2852
.
38.
Shi
,
Y.
,
Niu
,
J.
,
Cao
,
Z.
,
Cai
,
M.
,
Zhu
,
J.
, and
Xu
,
W.
,
2016
, “
Online Estimation Method for Respiratory Parameters Based on a Pneumatic Model
,”
IEEE/ACM Trans. Comput. Biol. Bioinf.
,
13
(
5
), pp.
939
946
.
You do not currently have access to this content.