This study concerns the development and preliminary experimental verification of a topological sensitivity–based platform for the material characterization of tissue anomalies exposed by vibroacoustography-type imaging techniques. Vibroacoustography (VA) is a high-resolution imaging method that has been applied to the detection of pathological changes in soft tissues. Although the data provided by this method is related to the mechanical properties of tissue, the viscoelastic parameters of the object cannot be estimated by this imaging method itself. Topological sensitivity (TS) method is a data processing methodology that can be used to estimate the viscoelastic parameters of an object from vibration data. In this study, the concept of topological sensitivity is applied to interpret the vibroacoustography measurements for the purpose of lesion characterization. In the proposed approach, the topological sensitivity function, which signifies the variation of a given cost functional when an infinitesimal inclusion with trial material parameters is placed at the location of a point force, is formulated in terms of the adjoint field. The effectiveness of the resulting formula as a material indicator for lesion characterization is demonstrated by estimating the relative elastic parameters of a well-controlled neoprene sphere embedded in a tissue-mimicking phantom specimen.
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Department of Hydraulic Engineering,
Tsinghua University,
e-mail: huinayuan@tsinghua.edu.cn
University of Minnesota,
e-mail: guzina@wave.ce.umn.edu
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July 2013
Technical Briefs
Application of Topological Sensitivity Toward Soft-Tissue Characterization From Vibroacoustography Measurements
Huina Yuan,
Department of Hydraulic Engineering,
Tsinghua University,
e-mail: huinayuan@tsinghua.edu.cn
Huina Yuan
1
State Key Laboratory of Hydroscience and Engineering
,Department of Hydraulic Engineering,
Tsinghua University,
Beijing 100084
, China
e-mail: huinayuan@tsinghua.edu.cn
1Corresponding author.
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Bojan B. Guzina,
University of Minnesota,
e-mail: guzina@wave.ce.umn.edu
Bojan B. Guzina
Department of Civil Engineering
,University of Minnesota,
Minneapolis, MN 55455
e-mail: guzina@wave.ce.umn.edu
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Randall Kinnick,
Mostafa Fatemi
Mostafa Fatemi
e-mail: fatemi.mostafa@mayo.edu
Mayo Clinic College of Medicine,
Department of Physiology and Biomedical Engineering
,Mayo Clinic College of Medicine,
Rochester, MN 55905
Search for other works by this author on:
Huina Yuan
State Key Laboratory of Hydroscience and Engineering
,Department of Hydraulic Engineering,
Tsinghua University,
Beijing 100084
, China
e-mail: huinayuan@tsinghua.edu.cn
Bojan B. Guzina
Department of Civil Engineering
,University of Minnesota,
Minneapolis, MN 55455
e-mail: guzina@wave.ce.umn.edu
Shigao Chen
e-mail: chen.shigao@mayo.edu
Randall Kinnick
e-mail: kinnick.randall@mayo.edu
Mostafa Fatemi
e-mail: fatemi.mostafa@mayo.edu
Mayo Clinic College of Medicine,
Department of Physiology and Biomedical Engineering
,Mayo Clinic College of Medicine,
Rochester, MN 55905
1Corresponding author.
Contributed by the Design Engineering Division of ASME for publication in the Journal of Computational and Nonlinear Dynamics. Manuscript received July 14, 2011; final manuscript received January 27, 2013; published online March 21, 2013. Assoc. Editor: Ahmed Al-Jumaily.
J. Comput. Nonlinear Dynam. Jul 2013, 8(3): 034503 (6 pages)
Published Online: March 21, 2013
Article history
Received:
July 14, 2011
Revision Received:
January 27, 2013
Citation
Yuan, H., Guzina, B. B., Chen, S., Kinnick, R., and Fatemi, M. (March 21, 2013). "Application of Topological Sensitivity Toward Soft-Tissue Characterization From Vibroacoustography Measurements." ASME. J. Comput. Nonlinear Dynam. July 2013; 8(3): 034503. https://doi.org/10.1115/1.4023738
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