In this paper, a high-dimensional system of nearest-neighbor coupled neural networks with multiple delays is proposed. Nowadays, most present researches about neural networks have studied the connection between adjacent nodes. However, in practical applications, neural networks are extremely complicated. This paper further considers that there are still connection relationships between nonadjacent nodes, which reflect the intrinsic characteristics of neural networks more accurately because of the complexity of its topology. The influences of multiple delays on the local stability and Hopf bifurcation of the system are explored by selecting the sum of delays as bifurcation parameter and discussing the related characteristic equations. It is found that the dynamic behaviors of the system depend on the critical value of bifurcation. In addition, the conditions that ensure the stability of the system and the criteria of Hopf bifurcation are given. Finally, the correctness of the theoretical analyses is verified by numerical simulation.