In this paper, a class of large-scale systems with impulsive effect, input disturbance, and both variable and unbounded delays were investigated. On the assumption that all subsystems of the large-scale system can be exponentially stabilized, and the stabilizing feedbacks and corresponding Lyapunov functions (LFs) for the closed-loop systems are available, using the idea of vector Lyapunov method and M-matrix property, the intero-differential inequalities with variable and unbounded delays were constructed. By the stability analysis of the intero-differential inequalities, the sufficient conditions to ensure the robust exponential stability of the large-scale system were obtained. Finally, the correctness and validity of the methods was verified by two numerical examples.

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