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Keywords: calcium
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Journal Articles

Impact of Calcium Quantifications on Stent Expansions

Pengfei Dong, Hiram G. Bezerra, David L. Wilson, Linxia Gu
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2019, 141(2): 021010.
Paper No: BIO-18-1114
https://doi.org/10.1115/1.4042013
Published Online: December 12, 2018
...Pengfei Dong; Hiram G. Bezerra; David L. Wilson; Linxia Gu Severely calcified plaque is of great concern when planning and implementing a stenting intervention. In this work, computational models were developed to investigate the influence of calcium characteristics on stenting outcomes...
View Article titled, Impact of <span class="search-highlight">Calcium</span> Quantifications on Stent Expansions
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Topics: Stents, Stress, Biological tissues
Journal Articles

Hydrostatic Pressure Stimulation of Human Mesenchymal Stem Cells Seeded on Collagen-Based Artificial Extracellular Matrices

Ricarda Hess, Timothy Douglas, Kenneth A. Myers, Barbe Rentsch, Claudia Rentsch, Hartmut Worch, Nigel G. Shrive, David A. Hart, Dieter Scharnweber
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2010, 132(2): 021001.
https://doi.org/10.1115/1.4000194
Published Online: December 28, 2009
... the expression of alkaline phosphatase (ALP) at the protein- and mRNA levels, as well as for calcium accumulation. The timing of HP stimulation affected hMSC proliferation and expression of ALP activity. HP stimulation after 6 days was most effective at promoting ALP activity. CS-containing matrices promoted...
View Article titled, Hydrostatic Pressure Stimulation of Human Mesenchymal Stem Cells Seeded on Collagen-Based Artificial Extracellular Matrices
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Topics: Bone, Hydrostatic pressure, Proteins, Stem cells, Coatings, Polishing equipment
Journal Articles

Mechanisms of Strain-Mediated Mesenchymal Stem Cell Apoptosis

E. M. Kearney, P. J. Prendergast, V. A. Campbell
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. December 2008, 130(6): 061004.
https://doi.org/10.1115/1.2979870
Published Online: October 9, 2008
... the stretch-activated cation channel blocker gadolinium chloride, the L -type voltage-activated calcium channel blocker nicardipine, the c-jun N H 2 -terminal kinase (JNK) blocker D-JNK inhibitor 1, and the calpain inhibitor MDL 28170. Apoptosis was assessed through DNA fragmentation using the terminal...
View Article titled, Mechanisms of Strain-Mediated Mesenchymal Stem Cell Apoptosis
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Topics: DNA, Proteins, Signals, Stem cells, Stress, Tissue engineering, Gadolinium, Fluorescence, Biological tissues
Journal Articles

Endothelial Nitric Oxide Synthase and Calcium Production in Arterial Geometries: An Integrated Fluid Mechanics/Cell Model

A. Comerford, M. J. Plank, T. David
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2008, 130(1): 011010.
https://doi.org/10.1115/1.2838026
Published Online: February 11, 2008
... (ATP) are investigated in a variety of arterial geometries: a bifurcation with varying inner angle, and an artery bend. A mathematical model of endothelial calcium and endothelial nitric oxide synthase cellular dynamics is used to investigate spatial variations in the physiology of the endothelium...
View Article titled, Endothelial Nitric Oxide Synthase and <span class="search-highlight">Calcium</span> Production in Arterial Geometries: An Integrated Fluid Mechanics&#x2F;Cell Model
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Topics: Bifurcation, Exterior walls, Flow (Dynamics), Mass transfer, Endothelial cells
Journal Articles

A Novel Single-Photon Counting Technique Applied to Highly Sensitive Measurement of [ Ca 2 + ] i Transient in Human Aortic Smooth Muscle Cells

Shigeru Tada, Ken Okazaki
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. October 2006, 128(5): 777–781.
https://doi.org/10.1115/1.2264396
Published Online: April 28, 2006
... . 16 03 2005 28 04 2006 calcium muscle cellular biophysics biological techniques photon counting dyes shear flow laminar flow haemodynamics bioluminescence ultraweak photon-counting smooth muscle cells shear stress intracellular Ca 2+ biophoton Intracellular...
View Article titled, A Novel Single-Photon Counting Technique Applied to Highly Sensitive Measurement of [ Ca 2 + ] i Transient in Human Aortic Smooth Muscle Cells
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Topics: Emissions, Muscle, Photons, Shear stress, Transients (Dynamics), Luminescence
Journal Articles

An in Vitro Model of Neural Trauma: Device Characterization and Calcium Response to Mechanical Stretch

Donna M. Geddes, Robert S. Cargill, II
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. June 2001, 123(3): 247–255.
https://doi.org/10.1115/1.1374201
Published Online: January 11, 2001
... arbitrary and controlled via closed-loop feedback. Intracellular calcium [ Ca 2 + ] i alterations were recorded in real time throughout the imposed strain with an epifluorescent microscopy system. Peak change in [ Ca 2 + ] i , recovery of [ Ca 2 + ] i , and percent responding NG108-15 cells were shown...
View Article titled, An in Vitro Model of Neural Trauma: Device Characterization and <span class="search-highlight">Calcium</span> Response to Mechanical Stretch
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Topics: Deformation, Membranes, Displacement, Microscopy
Journal Articles

Selective Modulation of Endothelial Cell [ Ca 2 + ] i Response to Flow by the Onset Rate of Shear Stress

Brett R. Blackman, Lawrence E. Thibault, Kenneth A. Barbee
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. June 2000, 122(3): 274–282.
https://doi.org/10.1115/1.429660
Published Online: February 6, 2000
... of the shear stress magnitude and the onset rate. Intracellular free calcium concentration [ Ca 2 + ] i increased rapidly following the onset of flow, and the characteristics of the transient were modulated by both the shear stress magnitude and onset rate. ECs were most sensitive to shear stress applied...
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Topics: Endothelial cells, Flow (Dynamics), Shear stress