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Keyword: brain
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Journal Articles
Article Type: Research-Article
J Biomech Eng. March 2019, 141(3): 031001.
Paper No: BIO-17-1558
Published Online: January 18, 2019
... studies have investigated the biochemical and genetic aspects of ASD, whether and how mechanical characteristics of the autistic brain can modulate neuronal connectivity and cognition in ASD are unknown. Previously, it has been shown that ASD brains are characterized by abnormal white matter and...
Includes: Supplementary data
Journal Articles
Article Type: Research Papers
J Biomech Eng. November 2011, 133(11): 111007.
Published Online: December 8, 2011
...Yun-Seok Kang; Kevin Moorhouse; John H. Bolte, IV The ability to measure six degrees of freedom (6 DOF) head kinematics in motor vehicle crash conditions is important for assessing head-neck loads as well as brain injuries. A method for obtaining accurate 6 DOF head kinematics in short duration...
Journal Articles
Article Type: Research Papers
J Biomech Eng. July 2011, 133(7): 071009.
Published Online: July 29, 2011
...Benjamin S. Elkin; Ashok Ilankova; Barclay Morrison, III Stress relaxation tests using a custom designed microindentation device were performed on ten anatomic regions of fresh porcine brain (postmortem time <3 h). Using linear viscoelastic theory, a Prony series representation was used to...
Journal Articles
Article Type: Research Papers
J Biomech Eng. May 2011, 133(5): 051008.
Published Online: May 3, 2011
... metric G is assumed to vary smoothly over the domain. 09 12 2010 10 03 2011 28 03 2011 03 05 2011 03 05 2011 biological tissues biomechanics brain elasticity finite element analysis inverse problems cerebral aneurysms tissue property pointwise...
Journal Articles
Article Type: Research Papers
J Biomech Eng. April 2011, 133(4): 041006.
Published Online: March 15, 2011
... deformation. We demonstrate the use of this methodology by determining the minimal rheological arrangement, constitutive relationships, and model parameters for the structural response of various soft tissues, including ex vivo perfused porcine liver in indentation, ex vivo porcine brain cortical tissue in...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2011, 133(2): 021002.
Published Online: January 24, 2011
...Guanglei Li; Bingmei M. Fu The endothelial surface glycocalyx layer (SGL) and the basement membrane (BM) are two important components of the blood-brain barrier (BBB). They provide large resistance to solute transport across the BBB in addition to the tight junctions in the cleft between adjacent...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2010, 132(10): 101004.
Published Online: October 1, 2010
...Andrew K. Knutsen; Yulin V. Chang; Cindy M. Grimm; Ly Phan; Larry A. Taber; Philip V. Bayly Folding of the cerebral cortex is a critical phase of brain development in higher mammals but the biomechanics of folding remain incompletely understood. During folding, the growth of the cortical surface is...
Journal Articles
Article Type: Research Papers
J Biomech Eng. September 2010, 132(9): 091009.
Published Online: August 26, 2010
... parameters of interest, and acceptable magnitude of error when selecting the vascular domain will increase reliability of the results while decreasing computational time. 01 06 2009 16 02 2010 22 02 2010 26 08 2010 26 08 2010 blood vessels brain computational fluid dynamics...
Journal Articles
Article Type: Research Papers
J Biomech Eng. July 2010, 132(7): 071013.
Published Online: June 2, 2010
...Gang Xu; Andrew K. Knutsen; Krikor Dikranian; Christopher D. Kroenke; Philip V. Bayly; Larry A. Taber During human brain development, the cerebral cortex undergoes substantial folding, leading to its characteristic highly convoluted form. Folding is necessary to accommodate the expansion of the...
Journal Articles
Article Type: Research Papers
J Biomech Eng. May 2010, 132(5): 051008.
Published Online: March 29, 2010
...O. Ivanchenko; N. Sindhwani; A. Linninger Convection enhanced delivery is an attractive option for the treatment of several neurodegenerative diseases such as Parkinson, Alzheimer, and brain tumors. However, the occurrence of a backflow is a major problem impeding the widespread use of this...
Journal Articles
Article Type: Research Papers
J Biomech Eng. January 2010, 132(1): 011010.
Published Online: December 18, 2009
...Benjamin S. Elkin; Ashok Ilankovan; Barclay Morrison, III Age-dependent outcomes following traumatic brain injury motivate the study of brain injury biomechanics in experimental animal models at different stages of development. Finite element models of the rat brain are used to better understand...
Journal Articles
Article Type: Research Papers
J Biomech Eng. January 2010, 132(1): 011005.
Published Online: December 9, 2009
...Gang Xu; Philip S. Kemp; Joyce A. Hwu; Adam M. Beagley; Philip V. Bayly; Larry A. Taber Mechanical forces play an important role during brain development. In the early embryo, the anterior end of the neural tube enlarges and differentiates into the major brain subdivisions, including three...
Journal Articles
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111010.
Published Online: October 26, 2009
... was greater than that of interface friction. Taken together, these findings demonstrate the advantages of flash freezing in biomechanical studies of spine cord tissue. 02 12 2008 11 05 2009 01 09 2009 26 10 2009 biological tissues biomechanics biothermics brain finite...
Journal Articles
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111003.
Published Online: October 16, 2009
... successfully demonstrated the limitations of current classical FE methods and provided valuable insights into the damage mechanisms of vertebral bodies. 03 09 2008 20 05 2009 16 10 2009 biomechanics bone brain finite element analysis Osteoporotic vertebral compression...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2009, 131(10): 101013.
Published Online: September 17, 2009
... representative values for cerebral arterial tissue. 29 11 2008 04 07 2009 17 09 2009 biomechanics blood vessels brain diseases failure analysis fatigue finite element analysis haemodynamics proteins cerebral arteries multi-mechanism aneurysms structural damage model...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2009, 131(10): 101010.
Published Online: September 4, 2009
... anisotropic media biomechanics blood vessels brain diseases elasticity proteins shear strength aneurysm artery cerebral collagen membrane saccular Saccular cerebral aneurysms are detected in less than 5% of the human population and are usually diagnosed in elder people between the...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2009, 131(10): 101003.
Published Online: September 1, 2009
.... 20 11 2008 10 06 2009 01 09 2009 blood vessels brain cellular biophysics diseases haemodynamics neurophysiology physiological models shear flow Cerebral aneurysms are estimated to be prevalent in 1–5% of the adult population. Although most cerebral aneurysms remain...
Journal Articles
Article Type: Research Papers
J Biomech Eng. September 2009, 131(9): 091004.
Published Online: August 4, 2009
... biomechanics blood vessels brain diseases haemodynamics neurophysiology non-Newtonian flow pulsatile flow non-Newtonian fluid intracranial aneurysm shear stress ellipticity computational fluid dynamics rupture Aneurysms, local dilations of arterial walls, may continue to expand until...
Journal Articles
Article Type: Technology Review
J Biomech Eng. July 2009, 131(7): 074002.
Published Online: July 27, 2009
...Kazuto Masamoto; Kazuo Tanishita Oxygen is essential to maintaining normal brain function. A large body of evidence suggests that the partial pressure of oxygen ( p O 2 ) in brain tissue is physiologically maintained within a narrow range in accordance with region-specific brain activity. Since the...
Journal Articles
Article Type: Research Papers
J Biomech Eng. July 2009, 131(7): 071007.
Published Online: July 16, 2009
... distributions following CED into the spinal cord. Quantification of these transport fields provides an important step toward development of drug-specific transport models of infusion. biological tissues biomedical MRI biotransport brain drug delivery systems neurophysiology 06 11 2008 26 05...