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Keyword: Freezing
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Journal Articles
Article Type: Technical Briefs
J Biomech Eng. April 2014, 136(4): 044502.
Paper No: BIO-13-1380
Published Online: March 24, 2014
... biomechanical parameters, with only E f significantly reduced. Refrigerating growth plate explants for less than 48 h maintains their maximal stress, equilibrium stress, matrix modulus, and permeability. However, cold storage at 4 °C for more than 48 h and freezing storage at −20 °C significantly alter the...
Journal Articles
Article Type: Errata
J Biomech Eng. April 2011, 133(4): 047001.
Published Online: February 18, 2011
...A. Changoor; L. Fereydoonzad; A. Yaroshinsky; M. D. Buschmann 28 01 2011 18 02 2011 biological tissues biomechanics cellular biophysics electromechanical effects freezing refrigeration The percentage reduction in Ef due to 12 days of refrigeration at 4 ° C is...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. June 2010, 132(6): 064502.
Published Online: April 26, 2010
... procedures often necessitate a storage protocol, which may adversely affect the functional properties of cartilage. The effects of storage at either 4 ° C for periods of 6 days and 12 days, or during a single freeze-thaw cycle at − 20 ° C were examined in young bovine cartilage. Non-destructive...
Journal Articles
Article Type: Research Papers
J Biomech Eng. March 2010, 132(3): 031003.
Published Online: February 4, 2010
...-thaw ECM microstructure is determined by the deformation of ETs during cryopreservation, freezing-induced deformation of ETs was measured with a newly developed quantum dot (QD)-mediated cell image deformetry system using dermal equivalents as a model tissue. The dermal equivalents were constructed by...
Journal Articles
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111010.
Published Online: October 26, 2009
... tissue is complicated by the extreme compliance of the tissue. The objectives of this study were to determine the effect of flash freezing on both specimen preparation and mechanical response and to quantify the effect of small deviations in specimen geometry on mechanical behavior. Specimens of porcine...
Journal Articles
Article Type: Technology Review
J Biomech Eng. July 2009, 131(7): 074003.
Published Online: July 28, 2009
...Raghav Goel; Kyle Anderson; Joel Slaton; Franz Schmidlin; Greg Vercellotti; John Belcher; John C. Bischof Molecular adjuvants can be used to enhance the natural destructive mechanisms of freezing within tissue. This review discusses their use in the growing field of combinatorial or adjuvant...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074513.
Published Online: June 29, 2009
... pump out cytotoxic drugs from the intracellular space. In this study, we tested a hypothesis that freezing and thawing (F/T) may enhance intracellular drug delivery to MDR cancer cells via F/T-induced denaturation of MDR-associated proteins and/or membrane permeabilization. After a human MDR cancer...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074511.
Published Online: June 12, 2009
...Stéphanie Passot; Ioan Cristian Tréléa; Michèle Marin; Miquel Galan; G. John Morris; Fernanda Fonseca The freezing step influences lyophilization efficiency and protein stability. The main objective of this work was to investigate the impact on the primary drying stage of an ultrasound controlled...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074501.
Published Online: June 4, 2009
...Ioan Cristian Trelea; Stéphanie Passot; Michèle Marin; Fernanda Fonseca Lyophilizing frozen pellets, and especially spray freeze-drying, have been receiving growing interest. To design efficient and safe freeze-drying cycles, local temperature and moisture content in the product bed have to be...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074502.
Published Online: June 4, 2009
... is thus successfully predicted. The present approach suggests a highly efficient theoretical tool for probing into the freeze injury mechanisms of biological material due to ice formation during cryosurgery or cryopreservation process when external electric field was involved. 17 10 2008 25...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2009, 131(2): 021002.
Published Online: December 9, 2008
...Bumsoo Han; Jeffrey D. Miller; Jun K. Jung Freezing of biological tissue is emerging in various biomedical applications. The success of these applications requires precise control of the tissue functionality, which is closely associated with the microstructure of the extracellular matrix (ECM). In...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 688–694.
Published Online: February 14, 2007
... freezing. In the mixture of DMSO + EG , the respective values of L p g and E L p for equine tissue first cooled at 40 ° C ∕ min between + 25 ° C and + 4 ° C before being frozen were 0.15 μ m ∕ min atm and 7.6 kcal ∕ mole . The corresponding L p g and E L p values for equine tissue suspended in 1.6 M DMSO...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. December 2006, 128(6): 862–866.
Published Online: February 13, 2006
...M. Takahashi; S. Nomura; M. Jindai; S. Shibata; X. Zhu; Y. Watanabe; K. Kawachi; N. Okabe To minimize surgical stresses including blood loss and operation time to the patients during hepatic resection, we studied the feasibility of a combination of a partial liver freezing technique and shape...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. February 2006, 128(1): 49–58.
Published Online: September 19, 2005
...Daigo Tanaka; Kenji Shimada; Yoed Rabin Background : Cryosurgery is the destruction of undesired tissues by freezing, as in prostate cryosurgery, for example. Minimally invasive cryosurgery is currently performed by means of an array of cryoprobes, each in the shape of a long hypodermic needle. The...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. February 2005, 127(1): 67–84.
Published Online: March 8, 2005
... 07 October 2004 08 03 2005 biothermics cellular biophysics freezing mass transfer optical microscopes biological techniques The first practical light microscopes were invented and applied for laboratory studies of micro-organisms in the 1660’s by van Leeuwenhoek and Hooke...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. December 2004, 126(6): 736–744.
Published Online: February 4, 2005
...Loay Massalha; Avraham Shitzer The effects of a thermally-significant blood vessel, simulated by an embedded acrylic tube, 4.8 mm outer diameter, on the freezing field caused by a surface cryoprobe were studied experimentally in a tissue phantom. The flat, 15 mm diameter, circular cryoprobe was...
Journal Articles
Article Type: Article
J Biomech Eng. April 2005, 127(2): 295–300.
Published Online: December 6, 2004
... greatly simplifies the prediction of the optimal rate of freezing of biological systems. 21 04 2004 19 10 2004 06 12 2004 biothermics cellular biophysics biomembranes freezing permeability Cryopreservation Membrane Permeability Activation Energy Water Transport...
Journal Articles
Article Type: Article
J Biomech Eng. April 2005, 127(2): 279–294.
Published Online: September 18, 2004
...Jiayao Zhang; George A. Sandison; Jayathi Y. Murthy; Lisa X. Xu A comprehensive computational framework to simulate heat transfer during the freezing process in prostate cancer cryosurgery is presented. Tissues are treated as nonideal materials wherein phase transition occurs over a temperature...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. April 2004, 126(2): 196–203.
Published Online: May 4, 2004
...Bumsoo Han; John C. Bischof Understanding the phase change behavior of biomaterials during freezing/thawing including their thermal properties at low temperatures is essential to design and improve cryobiology applications such as cryopreservation and cryosurgery. However, knowledge of phase change...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. December 2002, 124(6): 780–783.
Published Online: December 27, 2002
...Hiroshi Takamatsu, Associate Professor,; Norihiko Kumagae, Former Graduate Student, Recent studies show that during slow freezing of biological cells, the cells may be also injured by not only chemical damage but also mechanical damage induced by ice crystal compression. A new experimental...