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Keefe B. Manning
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Journal Articles

Fluid Dynamic Study of the Penn State Pediatric Total Artificial Heart

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Cody Kubicki, Emma Raich, Peter Selinsky, Sailahari Ponnaluri, William J. Weiss, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2024, 146(10): 101007.
Paper No: BIO-23-1410
https://doi.org/10.1115/1.4065377
Published Online: May 13, 2024
View Articletitled, Fluid Dynamic Study of the Penn State Pediatric Total Artificial Heart
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Topics: Artificial hearts, Flow (Dynamics), Fluids, Particle image velocimetry, Pediatrics, Pumps, Rotational flow, Thrombosis, Valves
Includes: Supplementary data
Journal Articles

The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics

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Sailahari V. Ponnaluri, Michael S. Sacks, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2023, 145(3): 031005.
Paper No: BIO-22-1215
https://doi.org/10.1115/1.4056291
Published Online: December 9, 2022
View Articletitled, The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics
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Topics: Flow (Dynamics), Valves, Pressure, Cycles, Turbulence
Journal Articles

Experimental Hemodynamics Within the Penn State Fontan Circulatory Assist Device

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Sailahari V. Ponnaluri, Emma J. Christensen, Bryan C. Good, Cody J. Kubicki, Steven Deutsch, Joshua P. Cysyk, William J. Weiss, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2022, 144(7): 071004.
Paper No: BIO-21-1273
https://doi.org/10.1115/1.4053210
Published Online: February 15, 2022
View Articletitled, Experimental Hemodynamics Within the Penn State Fontan Circulatory Assist Device
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Topics: Flow (Dynamics), Pumps, Hemodynamics, Rotors, Physiology
Journal Articles

Characterizing the HeartMate II Left Ventricular Assist Device Outflow Using Particle Image Velocimetry

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Grant W. Rowlands, Bryan C. Good, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2018, 140(7): 071008.
Paper No: BIO-17-1326
https://doi.org/10.1115/1.4039822
Published Online: April 30, 2018
View Articletitled, Characterizing the HeartMate II Left Ventricular Assist Device Outflow Using Particle Image Velocimetry
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Topics: Flow (Dynamics), Particulate matter, Stress, Cardiac cycle, Ventricular assist devices, Physiology, Pumps, Shear stress
Journal Articles

Toward the Virtual Benchmarking of Pneumatic Ventricular Assist Devices: Application of a Novel Fluid–Structure Interaction-Based Strategy to the Penn State 12 cc Device

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Alessandro Caimi, Francesco Sturla, Bryan Good, Marco Vidotto, Rachele De Ponti, Filippo Piatti, Keefe B. Manning, Alberto Redaelli
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2017, 139(8): 081008.
Paper No: BIO-17-1034
https://doi.org/10.1115/1.4036936
Published Online: June 16, 2017
View Articletitled, Toward the Virtual Benchmarking of Pneumatic Ventricular Assist Devices: Application of a Novel Fluid–Structure Interaction-Based Strategy to the Penn State 12 cc Device
Open the PDF for Toward the Virtual Benchmarking of Pneumatic Ventricular Assist Devices: Application of a Novel Fluid–Structure Interaction-Based Strategy to the Penn State 12 cc Device in another window
Topics: Blood, Diaphragms (Mechanical devices), Diaphragms (Structural), Fluid structure interaction, Fluids, Valves, Fluid dynamics, Ventricular assist devices, Dynamics (Mechanics), Flow (Dynamics)
Includes: Supplementary data
Journal Articles

A Computational Method for Predicting Inferior Vena Cava Filter Performance on a Patient-Specific Basis

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Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Shankar P. Sastry, Suzanne M. Shontz, Frank C. Lynch, Brent A. Craven
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2014, 136(8): 081003.
Paper No: BIO-13-1517
https://doi.org/10.1115/1.4027612
Published Online: June 2, 2014
View Articletitled, A Computational Method for Predicting Inferior Vena Cava Filter Performance on a Patient-Specific Basis
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Topics: Filters, Flow (Dynamics), Hemodynamics
Journal Articles

In Vitro Quantification of Time Dependent Thrombus Size Using Magnetic Resonance Imaging and Computational Simulations of Thrombus Surface Shear Stresses

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Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2014, 136(7): 071012.
Paper No: BIO-13-1526
https://doi.org/10.1115/1.4027613
Published Online: May 23, 2014
View Articletitled, In Vitro Quantification of Time Dependent Thrombus Size Using Magnetic Resonance Imaging and Computational Simulations of Thrombus Surface Shear Stresses
Open the PDF for In Vitro Quantification of Time Dependent Thrombus Size Using Magnetic Resonance Imaging and Computational Simulations of Thrombus Surface Shear Stresses in another window
Topics: Thrombosis, Magnetic resonance imaging, Blood flow, Computational fluid dynamics, Flow (Dynamics), Simulation
Journal Articles

An In Vitro Fluid Dynamic Study of Pediatric Cannulae: The Value of Animal Studies to Predict Human Flow

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Tobias C. Long, Joseph J. Pearson, Andrew C. Hankinson, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2012, 134(4): 044501.
https://doi.org/10.1115/1.4006428
Published Online: April 20, 2012
View Articletitled, An In Vitro Fluid Dynamic Study of Pediatric Cannulae: The Value of Animal Studies to Predict Human Flow
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Topics: Blood, Flow (Dynamics), Fluid dynamics, Fluids, Pediatrics, Particulate matter, Valves, Pressure drop
Journal Articles

A Fluid Dynamics Study in a 50 cc Pulsatile Ventricular Assist Device: Influence of Heart Rate Variability

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Jason C. Nanna, Michael A. Navitsky, Stephen R. Topper, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. October 2011, 133(10): 101002.
https://doi.org/10.1115/1.4005001
Published Online: October 31, 2011
View Articletitled, A Fluid Dynamics Study in a 50 cc Pulsatile Ventricular Assist Device: Influence of Heart Rate Variability
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Topics: Flow (Dynamics), Magnification, Shear rate, Thrombosis, Ventricular assist devices, Shear (Mechanics), Data collection, Fluid dynamics, Pumps, Cardiac cycle
Journal Articles

Multilaboratory Particle Image Velocimetry Analysis of the FDA Benchmark Nozzle Model to Support Validation of Computational Fluid Dynamics Simulations

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Prasanna Hariharan, Matthew Giarra, Varun Reddy, Steven W. Day, Keefe B. Manning, Steven Deutsch, Sandy F. C. Stewart, Matthew R. Myers, Michael R. Berman, Greg W. Burgreen, Eric G. Paterson, Richard A. Malinauskas
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. April 2011, 133(4): 041002.
https://doi.org/10.1115/1.4003440
Published Online: February 17, 2011
View Articletitled, Multilaboratory Particle Image Velocimetry Analysis of the FDA Benchmark Nozzle Model to Support Validation of Computational Fluid Dynamics Simulations
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Topics: Computational fluid dynamics, Flow (Dynamics), Nozzles, Turbulence, Particulate matter, Simulation, Fluids, Food and Drug Administration, Uncertainty, Reynolds number
Journal Articles

Hemodynamics of an End-to-Side Anastomotic Graft for a Pulsatile Pediatric Ventricular Assist Device

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Ning Yang, Steven Deutsch, Eric G. Paterson, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. March 2010, 132(3): 031009.
https://doi.org/10.1115/1.4000872
Published Online: February 17, 2010
View Articletitled, Hemodynamics of an End-to-Side Anastomotic Graft for a Pulsatile Pediatric Ventricular Assist Device
Open the PDF for Hemodynamics of an End-to-Side Anastomotic Graft for a Pulsatile Pediatric Ventricular Assist Device in another window
Topics: Aorta, Flow (Dynamics), Pediatrics, Ventricular assist devices, Vessels, Turbulence, Hemodynamics, Cycles
Journal Articles

Validation of a CFD Methodology for Positive Displacement LVAD Analysis Using PIV Data

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Richard B. Medvitz, Varun Reddy, Steve Deutsch, Keefe B. Manning, Eric G. Paterson
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111009.
https://doi.org/10.1115/1.4000116
Published Online: October 21, 2009
View Articletitled, Validation of a CFD Methodology for Positive Displacement LVAD Analysis Using PIV Data
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Topics: Computational fluid dynamics, Flow (Dynamics), Valves, Displacement, Shear (Mechanics)
Journal Articles

Numerical Study of Blood Flow at the End-to-Side Anastomosis of a Left Ventricular Assist Device for Adult Patients

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Ning Yang, Steven Deutsch, Eric G. Paterson, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111005.
https://doi.org/10.1115/1.3212114
Published Online: October 16, 2009
View Articletitled, Numerical Study of Blood Flow at the End-to-Side Anastomosis of a Left Ventricular Assist Device for Adult Patients
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Topics: Aorta, Flow (Dynamics), Turbulence, Ventricular assist devices, Vessels
Journal Articles

Modifying a Tilting Disk Mechanical Heart Valve Design to Improve Closing Dynamics

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Luke H. Herbertson, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. October 2008, 130(5): 054503.
https://doi.org/10.1115/1.2978987
Published Online: September 17, 2008
View Articletitled, Modifying a Tilting Disk Mechanical Heart Valve Design to Improve Closing Dynamics
Open the PDF for Modifying a Tilting Disk Mechanical Heart Valve Design to Improve Closing Dynamics in another window
Topics: Cavitation, Design, Disks, Dynamics (Mechanics), Heart valve prostheses, Valves, Pressure, Acoustics
Journal Articles

The 12 cc Penn State Pulsatile Pediatric Ventricular Assist Device: Fluid Dynamics Associated With Valve Selection

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Benjamin T. Cooper, Breigh N. Roszelle, Tobias C. Long, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. August 2008, 130(4): 041019.
https://doi.org/10.1115/1.2939342
Published Online: June 24, 2008
View Articletitled, The 12 cc Penn State Pulsatile Pediatric Ventricular Assist Device: Fluid Dynamics Associated With Valve Selection
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Topics: Flow (Dynamics), Pediatrics, Rotational flow, Shear (Mechanics), Valves, Ventricular assist devices, Shear rate, Jets
Journal Articles

A Detailed Fluid Mechanics Study of Tilting Disk Mechanical Heart Valve Closure and the Implications to Blood Damage

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Keefe B. Manning, Ph.D., Luke H. Herbertson, Arnold A. Fontaine, Steven Deutsch
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. August 2008, 130(4): 041001.
https://doi.org/10.1115/1.2927356
Published Online: May 16, 2008
View Articletitled, A Detailed Fluid Mechanics Study of Tilting Disk Mechanical Heart Valve Closure and the Implications to Blood Damage
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Topics: Blood, Damage, Disks, Flow (Dynamics), Fluid mechanics, Heart valve prostheses, Shear rate, Valves, Vortices, Cavitation
Journal Articles

Wavelet Transforms in the Analysis of Mechanical Heart Valve Cavitation

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Luke H. Herbertson, Varun Reddy, Keefe B. Manning, Joseph P. Welz, Arnold A. Fontaine, Steven Deutsch
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. April 2006, 128(2): 217–222.
https://doi.org/10.1115/1.2165694
Published Online: September 21, 2005
View Articletitled, Wavelet Transforms in the Analysis of Mechanical Heart Valve Cavitation
Open the PDF for Wavelet Transforms in the Analysis of Mechanical Heart Valve Cavitation in another window
Topics: Cavitation, Heart valve prostheses, Signals, Valves, Wavelets, Wavelet transforms
Journal Articles

Fluid Dynamic Analysis of the 50 cc Penn State Artificial Heart Under Physiological Operating Conditions Using Particle Image Velocimetry

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Pramote Hochareon, Keefe B. Manning, Arnold A. Fontaine, John M. Tarbell, Steven Deutsch
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2004, 126(5): 585–593.
https://doi.org/10.1115/1.1798056
Published Online: November 23, 2004
View Articletitled, Fluid Dynamic Analysis of the 50 cc Penn State Artificial Heart Under Physiological Operating Conditions Using Particle Image Velocimetry
Open the PDF for Fluid Dynamic Analysis of the 50 cc Penn State Artificial Heart Under Physiological Operating Conditions Using Particle Image Velocimetry in another window
Topics: Artificial hearts, Flow (Dynamics), Particulate matter, Shear rate, Fluids, Valves, Gates (Closures), Rotational flow
Journal Articles

Wall Shear-Rate Estimation Within the 50cc Penn State Artificial Heart Using Particle Image Velocimetry

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Pramote Hochareon, Keefe B. Manning, Arnold A. Fontaine, John M. Tarbell, Steven Deutsch
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. August 2004, 126(4): 430–437.
https://doi.org/10.1115/1.1784477
Published Online: September 27, 2004
View Articletitled, Wall Shear-Rate Estimation Within the 50cc Penn State Artificial Heart Using Particle Image Velocimetry
Open the PDF for Wall Shear-Rate Estimation Within the 50cc Penn State Artificial Heart Using Particle Image Velocimetry in another window
Topics: Artificial hearts, Particulate matter, Shear rate, Flow (Dynamics), Algorithms, Simulation, Displacement, Fluids, Magnification
Journal Articles

A New Method for Evaluation of Cavitation Near Mechanical Heart Valves

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Peter Johansen, Keefe B. Manning, John M. Tarbell, Arnold A. Fontaine, Steven Deutsch, Hans Nygaard
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2003, 125(5): 663–670.
https://doi.org/10.1115/1.1613297
Published Online: October 9, 2003
View Articletitled, A New Method for Evaluation of Cavitation Near Mechanical Heart Valves
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Topics: Cavitation, Signals, Valves, Pressure, Filters