Abstract
To precisely control protein activity in a living system is a challenging yet long-pursued objective in biomedical sciences. Recently, we have developed a new approach named molecular hyperthermia (MH) to photoinactivate protein activity of interest without genetic modification. MH utilizes nanosecond laser pulse to create nanoscale heating around plasmonic nanoparticles to inactivate adjacent protein in live cells. Here we use a numerical model to study important parameters and conditions for MH to efficiently inactivate proteins in nanoscale. To quantify the protein inactivation process, the impact zone is defined as the range where proteins are inactivated by the nanoparticle localized heating. Factors that reduce the MH impact zone include the laser pulse duration, temperature-dependent thermal conductivity (versus constant properties), and nonspherical nanoparticle geometry. In contrast, the impact zone is insensitive to temperature-dependent material density and specific heat, as well as thermal interface resistance based on reported data in the literature. The low thermal conductivity of cytoplasm increases the impact zone. Different proteins with various Arrhenius kinetic parameters have significantly different impact zones. This study provides guidelines to design the protein inactivation process by MH.
Issue Section:
Research Papers
References
1.
Hoorens
,
M. W. H.
, and
Szymanski
,
W.
, 2018
, “
Reversible, Spatial and Temporal Control Over Protein Activity Using Light
,” Trends Biochem. Sci.
,
43
(8
), pp. 567
–575
.10.1016/j.tibs.2018.05.0042.
Kim
,
C. K.
,
Adhikari
,
A.
, and
Deisseroth
,
K.
, 2017
, “
Integration of Optogenetics With Complementary Methodologies in Systems Neuroscience
,” Nat. Rev. Neurosci.
,
18
(4
), pp. 222
–235
.10.1038/nrn.2017.153.
Gomez-Santacana
,
X.
,
de Munnik
,
S. M.
,
Vijayachandran
,
P.
,
Da Costa Pereira
,
D.
,
Bebelman
,
J. P. M.
,
de Esch
,
I. J. P.
,
Vischer
,
H. F.
,
Wijtmans
,
M.
, and
Leurs
,
R.
, 2018
, “
Photoswitching the Efficacy of a Small-Molecule Ligand for a Peptidergic GPCR: From Antagonism to Agonism
,” Angew. Chem., Int. Ed. Engl.
,
57
(36
), pp. 11608
–11612
.10.1002/anie.2018048754.
Fehrentz
,
T.
,
Huber
,
F. M. E.
,
Hartrampf
,
N.
,
Bruegmann
,
T.
,
Frank
,
J. A.
,
Fine
,
N. H. F.
,
Malan
,
D.
,
Danzl
,
J. G.
,
Tikhonov
,
D. B.
,
Sumser
,
M.
,
Sasse
,
P.
,
Hodson
,
D. J.
,
Zhorov
,
B. S.
,
Klocker
,
N.
, and
Trauner
,
D.
, 2018
, “
Optical Control of L-Type Ca2+ Channels Using a Diltiazem Photoswitch
,” Nat. Chem. Biol.
,
14
(8
), pp. 764
–767
.10.1038/s41589-018-0090-85.
Goodman
,
A. M.
,
Hogan
,
N. J.
,
Gottheim
,
S.
,
Li
,
C.
,
Clare
,
S. E.
, and
Halas
,
N. J.
, 2017
, “
Understanding Resonant Light-Triggered DNA Release From Plasmonic Nanoparticles
,” ACS Nano
,
11
(1
), pp. 171
–179
.10.1021/acsnano.6b065106.
Chen
,
S.
,
Weitemier
,
A. Z.
,
Zeng
,
X.
,
He
,
L.
,
Wang
,
X.
,
Tao
,
Y.
,
Huang
,
A. J. Y.
,
Hashimotodani
,
Y.
,
Kano
,
M.
,
Iwasaki
,
H.
,
Parajuli
,
L. K.
,
Okabe
,
S.
,
Teh
,
D. B. L.
,
All
,
A. H.
,
Tsutsui-Kimura
,
I.
,
Tanaka
,
K. F.
,
Liu
,
X.
, and
McHugh
,
T. J.
, 2018
, “
Near-Infrared Deep Brain Stimulation Via Upconversion Nanoparticle-Mediated Optogenetics
,” Science
,
359
(6376
), pp. 679
–684
.10.1126/science.aaq11447.
Huang
,
H.
,
Delikanli
,
S.
,
Zeng
,
H.
,
Ferkey
,
D. M.
, and
Pralle
,
A.
, 2010
, “
Remote Control of Ion Channels and Neurons Through Magnetic-Field Heating of Nanoparticles
,” Nat. Nanotechnol.
,
5
(8
), pp. 602
–606
.10.1038/nnano.2010.1258.
Ma
,
X.
,
Xiong
,
Y.
, and
Lee
,
L. T.
, O., 2018
, “
Application of Nanoparticles for Targeting G Protein-Coupled Receptors
,” Int. J. Mol. Sci.
,
19
(7
), p. 2006
.10.3390/ijms190720069.
Hartland
,
G. V.
, 2011
, “
Optical Studies of Dynamics in Noble Metal Nanostructures
,” Chem. Rev.
,
111
(6
), pp. 3858
–3887
.10.1021/cr100254710.
Huang
,
X.
,
Jain
,
P. K.
,
El-Sayed
,
I. H.
, and
El-Sayed
,
M. A.
, 2008
, “
Plasmonic Photothermal Therapy (Pptt) Using Gold Nanoparticles
,” Lasers Med. Sci.
,
23
(3
), pp. 217
–228
.10.1007/s10103-007-0470-x11.
Paviolo
,
C.
, and
Stoddart
,
P. R.
, 2017
, “
Gold Nanoparticles for Modulating Neuronal Behavior
,” Nanomaterials (Basel)
,
7
(4
), p. 92
.10.3390/nano704009212.
Lavoie-Cardinal
,
F.
,
Salesse
,
C.
,
Bergeron
,
E.
,
Meunier
,
M.
, and
De Koninck
,
P.
, 2016
, “
Gold Nanoparticle-Assisted All Optical Localized Stimulation and Monitoring of Ca2+ Signaling in Neurons
,” Sci. Rep.
,
6
, p. 20619
.10.1038/srep2061913.
Carvalho-de-Souza
,
J. L.
,
Treger
,
J. S.
,
Dang
,
B.
,
Kent
,
S. B.
,
Pepperberg
,
D. R.
, and
Bezanilla
,
F.
, 2015
, “
Photosensitivity of Neurons Enabled by Cell-Targeted Gold Nanoparticles
,” Neuron
,
86
(1
), pp. 207
–217
.10.1016/j.neuron.2015.02.03314.
Robert
,
H. M. L.
,
Savatier
,
J.
,
Vial
,
S.
,
Verghese
,
J.
,
Wattellier
,
B.
,
Rigneault
,
H.
,
Monneret
,
S.
,
Polleux
,
J.
, and
Baffou
,
G.
, 2018
, “
Photothermal Control of Heat-Shock Protein Expression at the Single Cell Level
,” Small
,
14
(32
), p. 1801910
.10.1002/smll.20180191015.
Wilson
,
A. M.
,
Mazzaferri
,
J.
,
Bergeron
,
E.
,
Patskovsky
,
S.
,
Marcoux-Valiquette
,
P.
,
Costantino
,
S.
,
Sapieha
,
P.
, and
Meunier
,
M.
, 2018
, “
In Vivo Laser-Mediated Retinal Ganglion Cell Optoporation Using Kv1.1 Conjugated Gold Nanoparticles
,” Nano Lett.
,
18
(11
), pp. 6981
–6988
.10.1021/acs.nanolett.8b0289616.
Li
,
X.
,
Kang
,
P.
,
Chen
,
Z.
,
Lal
,
S.
,
Zhang
,
L.
,
Gassensmith
,
J. J.
, and
Qin
,
Z.
, 2018
, “
Rock the Nucleus: Significantly Enhanced Nuclear Membrane Permeability and Gene Transfection by Plasmonic Nanobubble Induced Nanomechanical Transduction
,” Chem. Commun. (Cambridge, U. K.)
,
54
(20
), pp. 2479
–2482
.10.1039/C7CC09613E17.
Baffou
,
G.
, and
Quidant
,
R.
, 2013
, “
Thermo-Plasmonics: Using Metallic Nanostructures as Nano-Sources of Heat
,” Laser Photon. Rev.
,
7
(2
), pp. 171
–187
.10.1002/lpor.20120000318.
Qin
,
Z.
, and
Bischof
,
J. C.
, 2012
, “
Thermophysical and Biological Responses of Gold Nanoparticle Laser Heating
,” Chem. Soc. Rev.
,
41
(3
), pp. 1191
–1217
.10.1039/C1CS15184C19.
Huttmann
,
G.
, and
Birngruber
,
R.
, 1999
, “
On the Possibility of High-Precision Photothermal Microeffects and the Measurement of Fast Thermal Denaturation of Proteins
,” IEEE J. Sel. Top. Quant.
,
5
(4
), pp. 954
–962
.10.1109/2944.79631720.
Hu
,
M.
, and
Hartland
,
G. V.
, 2002
, “
Heat Dissipation for Au Particles in Aqueous Solution: Relaxation Time Versus Size
,” J. Phys. Chem. B
,
106
(28
), pp. 7029
–7033
.10.1021/jp020581+21.
Keblinski
,
P.
,
Cahill
,
D. G.
,
Bodapati
,
A.
,
Sullivan
,
C. R.
, and
Taton
,
T. A.
, 2006
, “
Limits of Localized Heating by Electromagnetically Excited Nanoparticles
,” J. Appl. Phys.
,
100
(5
), p. 054305
.10.1063/1.233578322.
Baffou
,
G.
,
Quidant
,
R.
, and
Girard
,
C.
, 2010
, “
Thermoplasmonics Modeling: A Green's Function Approach
,” Phys. Rev. B
,
82
(16
), p. 165424
.10.1103/PhysRevB.82.16542423.
Richardson
,
H. H.
,
Carlson
,
M. T.
,
Tandler
,
P. J.
,
Hernandez
,
P.
, and
Govorov
,
A. O.
, 2009
, “
Experimental and Theoretical Studies of Light-to-Heat Conversion and Collective Heating Effects in Metal Nanoparticle Solutions
,” Nano Lett.
,
9
(3
), pp. 1139
–1146
.10.1021/nl803690524.
Baffou
,
G.
,
Berto
,
P.
,
Bermúdez Ureña
,
E.
,
Quidant
,
R.
,
Monneret
,
S.
,
Polleux
,
J.
, and
Rigneault
,
H.
, 2013
, “
Photoinduced Heating of Nanoparticle Arrays
,” ACS Nano
,
7
(8
), pp. 6478
–6488
.10.1021/nn401924n25.
Yakunin
,
A. N.
,
Avetisyan
,
Y. A.
, and
Tuchin
,
V. V.
, 2015
, “
Quantification of Laser Local Hyperthermia Induced by Gold Plasmonic Nanoparticles
,” J. Biomed. Opt.
,
20
(5
), p. 051030
.10.1117/1.JBO.20.5.05103026.
Huttmann
,
G.
,
Radt
,
B.
,
Serbin
,
J.
, and
Birngruber
,
R.
, 2003
, “
Inactivation of Proteins by Irradiation of Gold Nanoparticles With Nano- and Picosecond Laser Pulses
,” Proc. SPIE
,
5142
, pp. 88
–95
.10.1117/12.50052527.
Pitsillides
,
C. M.
,
Joe
,
E. K.
,
Wei
,
X.
,
Anderson
,
R. R.
, and
Lin
,
C. P.
, 2003
, “
Selective Cell Targeting With Light-Absorbing Microparticles and Nanoparticles
,” Biophys. J.
,
84
(6
), pp. 4023
–4032
.10.1016/S0006-3495(03)75128-528.
Takeda
,
Y.
,
Kondow
,
T.
, and
Mafune
,
F.
, 2006
, “
Degradation of Protein in Nanoplasma Generated Around Gold Nanoparticles in Solution by Laser Irradiation
,” J. Phys. Chem. B
,
110
(5
), pp. 2393
–2397
.10.1021/jp058204v29.
Kang
,
P.
,
Chen
,
Z.
,
Nielsen
,
S. O.
,
Hoyt
,
K.
,
D'Arcy
,
S.
,
Gassensmith
,
J. J.
, and
Qin
,
Z.
, 2017
, “
Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating
,” Small
,
13
(36
), pp. 1700841
–1700847
.10.1002/smll.20170084130.
Kang
,
P.
,
Li
,
X.
,
Liu
,
Y.
,
Shiers
,
S. I.
,
Xiong
,
H.
,
Giannotta
,
M.
,
Dejana
,
E.
,
Price
,
T. J.
,
Randrianalisoa
,
J.
,
Nielsen
,
S. O.
, and
Qin
,
Z.
, 2019
, “
Transient Photoinactivation of Cell Membrane Protein Activity Without Genetic Modification by Molecular Hyperthermia
,” ACS Nano
,
13
(11
), pp. 12487
–12499
.10.1021/acsnano.9b0199331.
Sarkar
,
D.
,
Kang
,
P.
,
Nielsen
,
S. O.
, and
Qin
,
Z.
, 2019
, “
Non-Arrhenius Reaction-Diffusion Kinetics for Protein Inactivation Over a Large Temperature Range
,” ACS Nano
,
13
(8
), pp. 8669
–8679
.10.1021/acsnano.9b0006832.
Dagallier
,
A.
,
Boulais
,
E.
,
Boutopoulos
,
C.
,
Lachaine
,
R.
, and
Meunier
,
M.
, 2017
, “
Multiscale Modeling of Plasmonic Enhanced Energy Transfer and Cavitation Around Laser-Excited Nanoparticles
,” Nanoscale
,
9
(9
), pp. 3023
–3032
.10.1039/C6NR08773F33.
Berto
,
P.
,
Mohamed
,
M. S. A.
,
Rigneault
,
H.
, and
Baffou
,
G.
, 2014
, “
Time-Harmonic Optical Heating of Plasmonic Nanoparticles
,” Phys. Rev. B
,
90
(3
), p. 035439
.10.1103/PhysRevB.90.03543934.
Chen
,
J. K.
,
Beraun
,
J. E.
, and
Tham
,
C. L.
, 2003
, “
Investigation of Thermal Response Caused by Pulse Laser Heating
,” Numer. Heat Transfer, Part A
,
44
(7
), pp. 705
–722
.10.1080/71610052035.
Bohren
,
C. F.
, and
Huffman
,
D. R.
, 1983
, Absorption and Scattering of Light by Small Particles
,
Wiley
,
New York
.36.
Goldenberg
,
H.
, and
Tranter
,
C. J.
, 1952
, “
Heat Flow in an Infinite Medium Heated by a Sphere
,” Br. J. Appl. Phys.
,
3
(9
), pp. 296
–298
.10.1088/0508-3443/3/9/30737.
Waxenegger
,
J.
,
Trügler
,
A.
, and
Hohenester
,
U.
, 2015
, “
Plasmonics Simulations With the Mnpbem Toolbox: Consideration of Substrates and Layer Structures
,” Comput. Phys. Comm.
,
193
, pp. 138
–150
.10.1016/j.cpc.2015.03.02338.
Johnson
,
P. B.
, and
Christy
,
R. W.
, 1972
, “
Optical Constants of the Noble Metals
,” Phys. Rev. B
,
6
(12
), pp. 4370
–4379
.10.1103/PhysRevB.6.437039.
Pohl
,
F. M.
, 1976
, “
Temperature-Dependence of the Kinetics of Folding of Chymotrypsinogen A
,” FEBS Lett.
,
65
(3
), pp. 293
–296
.10.1016/0014-5793(76)80132-940.
Yan
,
C.
,
Pattani
,
V.
,
Tunnell
,
J. W.
, and
Ren
,
P.
, 2010
, “
Temperature-Induced Unfolding of Epidermal Growth Factor (Egf): Insight From Molecular Dynamics Simulation
,” J. Mol. Graph. Modell.
,
29
(1
), pp. 2
–12
.10.1016/j.jmgm.2010.03.01141.
Eyring
,
H.
, and
Stearn
,
A. E.
, 1939
, “
The Application of the Theory of Absolute Reacton Rates to Proteins
,” Chem. Rev.
,
24
(2
), pp. 253
–270
.10.1021/cr60078a00542.
Hubbard
,
R.
, 1958
, “
The Thermal Stability of Rhodopsin and Opsin
,” J. General Physiol.
,
42
(2
), pp. 259
–280
.10.1085/jgp.42.2.25943.
Yoshioka
,
S.
, and
Stella
,
V. J.
, 2002
, “
Stability of Peptide and Protein Pharmaceuticals
,” Stability of Drugs and Dosage Forms
,
Springer US
,
Boston, MA
, pp. 187
–203
.44.
Nasser Brumano
,
M. H.
,
Rogana
,
E.
, and
Swaisgood
,
H. E.
, 2000
, “
Thermodynamics of Unfolding of Β-Trypsin at Ph 2.8
,” Arch. Biochem. Biophys.
,
382
(1
), pp. 57
–62
.10.1006/abbi.2000.198345.
Pina
,
D. G.
,
Shnyrova
,
A. V.
,
Gavilanes
,
F.
,
Rodríguez
,
A.
,
Leal
,
F.
,
Roig
,
M. G.
,
Sakharov
,
I. Y.
,
Zhadan
,
G. G.
,
Villar
,
E.
, and
Shnyrov
,
V. L.
, 2001
, “
Thermally Induced Conformational Changes in Horseradish Peroxidase
,” Eur. J. Biochem.
,
268
(1
), pp. 120
–126
.10.1046/j.1432-1033.2001.01855.x46.
Steel
,
B. C.
,
McKenzie
,
D. R.
,
Bilek
,
M. M.
,
Nosworthy
,
N. J.
, and
dos Remedios
,
C. G.
, 2006
, “
Nanosecond Responses of Proteins to Ultra-High Temperature Pulses
,” Biophys. J.
,
91
(6
), pp. L66
–L68
.10.1529/biophysj.106.09094447.
Yang
,
Z.
,
Zhou
,
Q.
,
Mok
,
L.
,
Singh
,
A.
,
Swartz
,
D. J.
,
Urbatsch
,
I. L.
, and
Brouillette
,
C. G.
, 2017
, “
Interactions and Cooperativity Between P-Glycoprotein Structural Domains Determined by Thermal Unfolding Provides Insights Into Its Solution Structure and Function
,” Biochim. Biophys. Acta (BBA) - Biomembr.
,
1859
(1
), pp. 48
–60
.10.1016/j.bbamem.2016.10.00948.
COMSOL,
2017
, “
Comsol Multiphysics® Reference Manual, Version 5.3
,” COMSOL
, Burlington, MA
, accessed Nov. 13, 2020, www.comsol.com49.
Pustovalov
,
V. K.
,
Smetannikov
,
A. S.
, and
Zharov
,
V. P.
, 2008
, “
Photothermal and Accompanied Phenomena of Selective Nanophotothermolysis With Gold Nanoparticles and Laser Pulses
,” Laser Phys. Lett.
,
5
(11
), pp. 775
–792
.10.1002/lapl.20081007250.
Tournus
,
F.
, 2011
, “
Random Nanoparticle Deposition: Inter-Particle Distances in 2d, 3d, and Multilayer Samples
,” J. Nanopart. Res.
,
13
(10
), pp. 5211
–5223
.10.1007/s11051-011-0506-951.
Terentyuk
,
G.
,
Maslyakova
,
G.
,
Suleymanova
,
L.
,
Khlebtsov
,
N.
,
Khlebtsov
,
B.
,
Akchurin
,
G.
,
Maksimova
,
I.
, and
Tuchin
,
V.
, 2009
, “
Laser-Induced Tissue Hyperthermia Mediated by Gold Nanoparticles: Toward Cancer Phototherapy
,” J. Biomed. Opt.
,
14
(2
), p. 021016
.10.1117/1.312237152.
Park
,
B. K.
,
Yi
,
N.
,
Park
,
J.
, and
Kim
,
D.
, 2013
, “
Thermal Conductivity of Single Biological Cells and Relation With Cell Viability
,” Appl. Phys. Lett.
,
102
(20
), p. 203702
.10.1063/1.480747153.
Park
,
B. K.
,
Yi
,
N.
,
Park
,
J.
,
Choi
,
T. Y.
,
Lee
,
J. Y.
,
Busnaina
,
A.
, and
Kim
,
D.
, 2011
, “
Thermal Conductivity of Bovine Serum Albumin: A Tool to Probe Denaturation of Protein
,” Appl. Phys. Lett.
,
99
(16
), p. 163702
.10.1063/1.365270454.
Zeskind
,
B. J.
,
Jordan
,
C. D.
,
Timp
,
W.
,
Trapani
,
L.
,
Waller
,
G.
,
Horodincu
,
V.
,
Ehrlich
,
D. J.
, and
Matsudaira
,
P.
, 2007
, “
Nucleic Acid and Protein Mass Mapping by Live-Cell Deep-Ultraviolet Microscopy
,” Nat. Methods
,
4
(7
), pp. 567
–569
.10.1038/nmeth105355.
Wilson
,
O. M.
,
Hu
,
X.
,
Cahill
,
D. G.
, and
Braun
,
P. V.
, 2002
, “
Colloidal Metal Particles as Probes of Nanoscale Thermal Transport in Fluids
,” Phys. Rev. B: Condens. Matter Mater. Phys.
,
66
(22
), p. 224301
.10.1103/PhysRevB.66.22430156.
Ge
,
Z.
,
Cahill
,
D. G.
, and
Braun
,
P. V.
, 2004
, “
Aupd Metal Nanoparticles as Probes of Nanoscale Thermal Transport in Aqueous Solution
,” J. Phys. Chem. B
,
108
(49
), pp. 18870
–18875
.10.1021/jp048375k57.
Ge
,
Z.
,
Cahill
,
D. G.
, and
Braun
,
P. V.
, 2006
, “
Thermal Conductance of Hydrophilic and Hydrophobic Interfaces
,” Phys. Rev. Lett.
,
96
(18
), p. 186101
.10.1103/PhysRevLett.96.18610158.
Plech
,
A.
,
Kotaidis
,
V.
,
Gresillon
,
S.
,
Dahmen
,
C.
, and
von Plessen
,
G.
, 2004
, “
Laser-Induced Heating and Melting of Gold Nanoparticles Studied by Time-Resolved X-Ray Scattering
,” Phys. Rev. B
,
70
(19
), p. 195423
.10.1103/PhysRevB.70.19542359.
Schmidt
,
A. J.
,
Alper
,
J. D.
,
Chiesa
,
M.
,
Chen
,
G.
,
Das
,
S. K.
, and
Hamad-Schifferli
,
K.
, 2008
, “
Probing the Gold Nanorod−Ligand−Solvent Interface by Plasmonic Absorption and Thermal Decay
,” J. Phys. Chem. C
,
112
(35
), pp. 13320
–13323
.10.1021/jp805188860.
Merabia
,
S.
,
Shenogin
,
S.
,
Joly
,
L.
,
Keblinski
,
P.
, and
Barrat
,
J. L.
, 2009
, “
Heat Transfer From Nanoparticles: A Corresponding State Analysis
,” Proc. Natl. Acad. Sci. U. S. A.
,
106
(36
), pp. 15113
–15118
.10.1073/pnas.090137210661.
Losego
,
M. D.
,
Grady
,
M. E.
,
Sottos
,
N. R.
,
Cahill
,
D. G.
, and
Braun
,
P. V.
, 2012
, “
Effects of Chemical Bonding on Heat Transport Across Interfaces
,” Nat. Mater.
,
11
(6
), pp. 502
–506
.10.1038/nmat330362.
Park
,
J.
,
Huang
,
J.
,
Wang
,
W.
,
Murphy
,
C. J.
, and
Cahill
,
D. G.
, 2012
, “
Heat Transport Between Au Nanorods, Surrounding Liquids, and Solid Supports
,” J. Phys. Chem. C
,
116
(50
), pp. 26335
–26341
.10.1021/jp308130d63.
Harikrishna
,
H.
,
Ducker
,
W. A.
, and
Huxtable
,
S. T.
, 2013
, “
The Influence of Interface Bonding on Thermal Transport Through Solid–Liquid Interfaces
,” Appl. Phys. Lett.
,
102
(25
), p. 251606
.10.1063/1.481274964.
Wu
,
X.
,
Ni
,
Y.
,
Zhu
,
J.
,
Burrows
,
N. D.
,
Murphy
,
C. J.
,
Dumitrica
,
T.
, and
Wang
,
X.
, 2016
, “
Thermal Transport Across Surfactant Layers on Gold Nanorods in Aqueous Solution
,” ACS Appl. Mater. Interfaces
,
8
(16
), pp. 10581
–10589
.10.1021/acsami.5b1216365.
Wei
,
X.
,
Zhang
,
T.
, and
Luo
,
T.
, 2017
, “
Thermal Energy Transport Across Hard–Soft Interfaces
,” ACS Energy Lett.
,
2
(10
), pp. 2283
–2292
.10.1021/acsenergylett.7b0057066.
Huxtable
,
S. T.
,
Cahill
,
D. G.
,
Shenogin
,
S.
,
Xue
,
L.
,
Ozisik
,
R.
,
Barone
,
P.
,
Usrey
,
M.
,
Strano
,
M. S.
,
Siddons
,
G.
,
Shim
,
M.
, and
Keblinski
,
P.
, 2003
, “
Interfacial Heat Flow in Carbon Nanotube Suspensions
,” Nat. Mater.
,
2
(11
), pp. 731
–734
.10.1038/nmat99667.
He
,
X.
, and
Bischof
,
J. C.
, 2003
, “
Quantification of Temperature and Injury Response in Thermal Therapy and Cryosurgery
,” Crit. Rev. Biomed. Eng.
,
31
(5&6
), pp. 355
–422
.10.1615/critrevbiomedeng.v31.i56.1068.
Qin
,
Z.
,
Balasubramanian
,
S. K.
,
Wolkers
,
W. F.
,
Pearce
,
J. A.
, and
Bischof
,
J. C.
, 2014
, “
Correlated Parameter Fit of Arrhenius Model for Thermal Denaturation of Proteins and Cells
,” Ann. Biomed. Eng.
,
42
(12
), pp. 2392
–2404
.10.1007/s10439-014-1100-y69.
Font
,
F.
, and
Myers
,
T. G.
, 2013
, “
Spherically Symmetric Nanoparticle Melting With a Variable Phase Change Temperature
,” J. Nanopart. Res.
,
15
, pp. 2086
–2099
.10.1007/s11051-013-2086-370.
Chen
,
X.
,
Munjiza
,
A.
,
Zhang
,
K.
, and
Wen
,
D.
, 2014
, “
Molecular Dynamics Simulation of Heat Transfer From a Gold Nanoparticle to a Water Pool
,” J. Phys. Chem. C
,
118
(2
), pp. 1285
–1293
.10.1021/jp410054j71.
Piana
,
S.
,
Lindorff-Larsen
,
K.
, and
Shaw
,
D. E.
, 2012
, “
Protein Folding Kinetics and Thermodynamics From Atomistic Simulation
,” Proc. Natl. Acad. Sci. U. S. A.
,
109
(44
), pp. 17845
–17850
.10.1073/pnas.1201811109Copyright © 2021 by ASME
You do not currently have access to this content.
