The efficacy of reduced order modeling for transstenotic pressure drop in the coronary arteries is presented. Coronary artery disease is a leading cause of death worldwide and the computation of pressure drop in the coronary arteries has become a standard for evaluating the functional significance of a coronary stenosis. Comprehensive models typically employ three-dimensional (3D) computational fluid dynamics (CFD) to simulate coronary blood flow in order to compute transstenotic pressure drop at the arterial stenosis. In this study, we evaluate the capability of different hydrodynamic models to compute transstenotic pressure drop. Models range from algebraic formulae to one-dimensional (1D), two-dimensional (2D), and 3D time-dependent CFD simulations. Although several algebraic pressure-drop formulae have been proposed in the literature, these models were found to exhibit wide variation in predictions. Nonetheless, we demonstrate an algebraic formula that provides consistent predictions with 3D CFD results for various changes in stenosis severity, morphology, location, and flow rate. The accounting of viscous dissipation and flow separation were found to be significant contributions to accurate reduce order modeling of transstenotic coronary hemodynamics.
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March 2019
Research-Article
Reduced Order Models for Transstenotic Pressure Drop in the Coronary Arteries
Mehran Mirramezani,
Mehran Mirramezani
Department of Mechanical Engineering,
University of California,
Berkeley, CA 94720;
University of California,
Berkeley, CA 94720;
Department of Mathematics,
University of California,
Berkeley, CA 94720
University of California,
Berkeley, CA 94720
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Scott L. Diamond,
Scott L. Diamond
Department of Chemical and
Biomolecular Engineering,
Institute for Medicine and Engineering,
University of Pennsylvania,
Philadelphia, PA 19104
Biomolecular Engineering,
Institute for Medicine and Engineering,
University of Pennsylvania,
Philadelphia, PA 19104
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Harold I. Litt,
Harold I. Litt
Department of Radiology,
Perelman School of Medicine
of the University of Pennsylvania,
Philadelphia, PA 19104
Perelman School of Medicine
of the University of Pennsylvania,
Philadelphia, PA 19104
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Shawn C. Shadden
Shawn C. Shadden
Department of Mechanical Engineering,
University of California,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
University of California,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
Search for other works by this author on:
Mehran Mirramezani
Department of Mechanical Engineering,
University of California,
Berkeley, CA 94720;
University of California,
Berkeley, CA 94720;
Department of Mathematics,
University of California,
Berkeley, CA 94720
University of California,
Berkeley, CA 94720
Scott L. Diamond
Department of Chemical and
Biomolecular Engineering,
Institute for Medicine and Engineering,
University of Pennsylvania,
Philadelphia, PA 19104
Biomolecular Engineering,
Institute for Medicine and Engineering,
University of Pennsylvania,
Philadelphia, PA 19104
Harold I. Litt
Department of Radiology,
Perelman School of Medicine
of the University of Pennsylvania,
Philadelphia, PA 19104
Perelman School of Medicine
of the University of Pennsylvania,
Philadelphia, PA 19104
Shawn C. Shadden
Department of Mechanical Engineering,
University of California,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
University of California,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
1Corresponding author.
2Technically, FFR = (Pdist−Pv/Pao−Pv), although central venous pressure (Pv < 8 mmHg) is often assumed negligible.
Manuscript received June 22, 2018; final manuscript received November 13, 2018; published online January 18, 2019. Assoc. Editor: Ching-Long Lin.
J Biomech Eng. Mar 2019, 141(3): 031005 (11 pages)
Published Online: January 18, 2019
Article history
Received:
June 22, 2018
Revised:
November 13, 2018
Citation
Mirramezani, M., Diamond, S. L., Litt, H. I., and Shadden, S. C. (January 18, 2019). "Reduced Order Models for Transstenotic Pressure Drop in the Coronary Arteries." ASME. J Biomech Eng. March 2019; 141(3): 031005. https://doi.org/10.1115/1.4042184
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