The porous structure of the natural bone not only has the characteristics of lightweight and high strength but also is conducive to the growth of cells and tissues due to interconnected pores. In this paper, a novel gradient-controlled parametric modeling technology is presented to design bone tissue engineering (BTE) scaffold. First of all, the method functionalizes the pore distribution in the bone tissue, and reconstructs the pore distribution of the bone tissue in combination with the pathological analysis of the bone defect area of the individual patient. Then, based on the reconstructed pore distribution, the Voronoi segmentation algorithm and the contour interface optimization method are used to reconstruct the whole model of the bone tissue. Finally, the mechanical properties of the scaffold are studied by the finite element analysis of different density gradient scaffolds. The results show that the method is highly feasible. BTE scaffold can be designed by irregular design methods and adjustment of pore distribution parameters, which is similar with natural bone in structural characteristics and biomechanical properties
Issue Section:
Research Papers
References
1.
Butler
, D. L.
, Goldstein
, S. A.
, and Guilak
, F.
, 2000
, “Functional Tissue Engineering: The Role of Biomechanics
,” ASME J. Biomech. Eng.
, 122
(6
), pp. 570
–575
.2.
Reddi
, A. H.
, and Cunningham
, N. S.
, 1991
, “Recent Progress in Bone Induction by Osteogenin and Bone Morphogenetic Proteins: Challenges for Biomechanical and Tissue Engineering
,” ASME J. Biomech. Eng.
, 113
(2
), pp. 189
–190
.3.
Khojasteh
, A.
, Behnia
, H.
, Dashti
, S. G.
, and Stevens
, M.
, 2012
, “Current Trends in Mesenchymal Stem Cell Application in Bone Augmentation: A Review of the Literature
,” J. Oral Maxillofac. Surg.
, 70
(4
), pp. 972
–982
.4.
Ma
, P. X.
, and Langer
, R.
, 1999
, “Fabrication of Biodegradable Polymer Foams for Cell Transplantation and Tissue Engineering
,” Tissue Engineering Methods and Protocols
(Methods in Molecular Medicine, Vol. 18), pp. 47
–56
.5.
P X
, M.
, 2003
, “Biomimetic Materials for Tissue Engineering
,” Adv. Drug Delivery Rev.
, 24
(24
), pp. 4353
–4364
.6.
Bawolin
, N. K.
, Dolovich
, A. T.
, Chen
, D. X. B.
, and Zhang
, C. W. J.
, 2015
, “Characterization of Mechanical Properties of Tissue Scaffolds by Phase Contrast Imaging and Finite Element Modeling
,” ASME J. Biomech. Eng.
, 137
(8
), p. 081004
.7.
Sumner
, D. R.
, 2015
, “Long-Term Implant Fixation and Stress-Shielding in Total Hip Replacement
,” J. Biomech.
, 48
(5
), pp. 797
–800
.8.
Cheah
, C. M.
, Chua
, C. K.
, Leong
, K. F.
, and Chua
, S. W.
, 2003
, “Development of a Tissue Engineering Scaffold Structure Library for Rapid Prototyping—Part 1: Investigation and Classification
,” Int. J. Adv. Manuf. Technol.
, 21
(4
), pp. 291
–301
.9.
Cheah
, C. M.
, Chua
, C. K.
, Leong
, K. F.
, and Chua
, S. W.
, 2003
, “Development of a Tissue Engineering Scaffold Structure Library for Rapid Prototyping—Part 2: Parametric Library and Assembly Program
,” Int. J. Adv. Manuf. Technol.
, 21
(4
), pp. 302
–312
.10.
Sun
, W.
, Starly
, B.
, Darling
, A.
, and Gomez
, C.
, 2005
, “Computer-Aided Tissue Engineering: Application to Biomimetic Modelling and Design of Tissue Scaffolds
,” J. Med. Biomech.
, 39
(1
), pp. 49
–58
.11.
Melchels
, F. P.
, Feijen
, J.
, and Grijpma
, D. W.
, 2009
, “A Poly(D,L-Lactide) Resin for the Preparation of Tissue Engineering Scaffolds by Stereolithography
,” Biomaterials
, 30
(23–24
), pp. 3801
–3809
.12.
Yoo
, D. J.
, 2011
, “Porous Scaffold Design Using the Distance Field and Triply Periodic Minimal Surface Models
,” Biomaterials
, 32
(31
), p. 7741
.13.
Kadkhodapour
, J.
, Montazerian
, H.
, and Raeisi
, S.
, 2014
, “Investigating Internal Architecture Effect in Plastic Deformation and Failure for TPMS-Based Scaffolds Using Simulation Methods and Experimental Procedure
,” Mater. Sci. Eng. C
, 43
, pp. 587
–597
.14.
Olivares
, A. L.
, Marsal
, E.
, Planell
, J. A.
, and Lacroix
, D.
, 2009
, “Finite Element Study of Scaffold Architecture Design and Culture Conditions for Tissue Engineering
,” Biomaterials
, 30
(30
), pp. 6142
–6149
.15.
Hollister
, S. J.
, and Kikuchi
, N.
, 1994
, “Homogenization Theory and Digital Imaging: A Basis for Studying the Mechanics and Design Principles of Bone Tissue
,” Biotechnol. Bioeng.
, 43
(7
), pp. 586
–596
.16.
Hollister
, S. J.
, and Lin
, C. Y.
, 2007
, “Computational Design of Tissue Engineering Scaffolds
,” Comput. Methods Appl. Mech. Eng.
, 196
(31–32
), pp. 2991
–2998
.17.
Lal
, P.
, and Sun
, W.
, 2004
, “Computer Modeling Approach for Microsphere-Packed Bone Scaffold
,” Comput.-Aided Des.
, 36
(5
), pp. 487
–497
.18.
Schroeder
, C.
, Regli
, W. C.
, Shokoufandeh
, A.
, and Sun
, W.
, 2005
, “Computer-Aided Design of Porous Artifacts
,” Comput.-Aided Des.
, 37
(3
), pp. 339
–353
.19.
Kou
, X. Y.
, and Tan
, S. T.
, 2010
, “A Simple and Effective Geometric Representation for Irregular Porous Structure Modeling
,” Comput.-Aided Des.
, 42
(10
), pp. 930
–941
.20.
Yang
, N.
, Gao
, L.
, and Zhou
, K.
, 2015
, “Simple Method to Generate and Fabricate Stochastic Porous Scaffolds
,” Mater. Sci. Eng. C
, 56
, pp. 444
–450
.21.
Wu
, J.
, Aage
, N.
, Westermann
, R.
, and Sigmund
, O.
, 2018
, “Infill Optimization for Additive Manufacturing—Approaching Bone-Like Porous Structures
,” IEEE Trans. Visualization Comput. Graphics
, 24
(2
), pp. 1127
–1140
.22.
Giannitelli
, S. M.
, Accoto
, D.
, Trombetta
, M.
, and Rainer
, A.
, 2014
, “Current Trends in the Design of Scaffolds for Computer-Aided Tissue Engineering
,” Acta Biomater.
, 10
(2
), pp. 580
–594
.23.
Najman
, L.
, and Schmitt
, M.
, 1994
, “Watershed of a Continuous Function
,” Signal Process.
, 38
(1
), pp. 99
–112
.24.
Aurenhammer
, F.
, 1991
, “Voronoi Diagrams—A Survey of a Fundamental Geometric Data Structure
,” ACM Comput. Surv.
, 23
(3
), pp. 345
–405
.25.
Stam
, J.
, 1998
, “Exact Evaluation of Catmull-Clark Subdivision Surfaces at Arbitrary Parameter Values
,” SIGGRAPH
, Orlando, FL, Vol. 98
, pp. 395
–404
.26.
Giordano
, R. A.
, Wu
, B. M.
, Borland
, S. W.
, Cima
, L. G.
, Sachs
, E. M.
, and Cima
, M. J.
, 1996
, “Mechanical Properties of Dense Polylactic Acid Structures Fabricated by Three Dimensional Printing
,” J. Biomater. Sci., Polym. Ed.
, 8
(1
), pp. 63
–75
.27.
Fantini
, M.
, Curto
, M.
, and Crescenzio
, F. D.
, 2016
, “A Method to Design Biomimetic Scaffolds for Bone Tissue Engineering Based on Voronoi Lattices
,” Virtual Phys. Prototyping
, 11
(2
), pp. 77
–90
.28.
Gómez
, S.
, Vlad
, M. D.
, López
, J.
, and Fernández
, E.
, 2016
, “Design and Properties of 3D Scaffolds for Bone Tissue Engineering
,” Acta Biomater.
, 42
, pp. 341
–350
.29.
Keaveny
, T. M.
, Morgan
, E. F.
, Niebur
, G. L.
, and Yeh
, O. C.
, 2001
, “Biomechanics of Trabecular Bone
,” Annu. Rev. Biomed. Eng.
, 3
(1
), pp. 307
–333
.30.
Gómez
, S.
, Vlad
, M. D.
, López
, J.
, Navarro
, M.
, and Fernández
, E.
, 2013
, “Characterization and Three-Dimensional Reconstruction of Synthetic Bone Model Foams
,” Mater. Sci. Eng. C
, 33
(6
), pp. 3329
–3335
.31.
Hollinger
, J. O.
, and Battistone
, G. C.
, 1986
, “Biodegradable Bone Repair Materials: Synthetic Polymers and Ceramics
,” Clin. Orthop. Relat. Res.
, 207
(207
), p. 290
.https://insights.ovid.com/crossref?an=00003086-198606000-0004632.
Hulbert
, S. F.
, Young
, F. A.
, Mathews
, R. S.
, Klawitter
, J. J.
, Talbert
, C. D.
, and Stelling
, F. H.
, 1970
, “Potential of Ceramic Materials as Permanently Implantable Skeletal Prostheses
,” J. Biomed. Mater. Res., Part A
, 4
(3
), p. 433
.33.
Kadir
, M. R. A.
, Syahrom
, A.
, and Öchsner
, A.
, 2010
, “Finite Element Analysis of Idealised Unit Cell Cancellous Structure Based on Morphological Indices of Cancellous Bone
,” Med. Biol. Eng. Comput.
, 48
(5
), pp. 497
–505
.34.
Ulrich
, D.
, van Rietbergen
, B.
, Laib
, A.
, and R¨uegsegger
, P.
, 1999
, “The Ability of Three-Dimensional Structural Indices to Reflect Mechanical Aspects of Trabecular Bone
,” Bone
, 25
(1
), pp. 55
–60
.35.
Hutmacher
, D. W.
, 2000
, “Scaffolds in Tissue Engineering Bone and Cartilage
,” Biomaterials
, 21
(24
), pp. 2529
–2543
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