Using the open-source software openfoam as the solver, a novel approach to calculate microsphere transport and deposition in a 1D human lung-equivalent trumpet model (TM) is presented. Specifically, for particle deposition in a nonlinear trumpetlike configuration a new radial force has been developed which, along with the regular drag force, generates particle trajectories toward the wall. The new semi-empirical force is a function of any given inlet volumetric flow rate, micron-particle diameter, and lung volume. Particle-deposition fractions (DFs) in the size range from 2 μm to 10 μm are in agreement with experimental datasets for different laminar and turbulent inhalation flow rates as well as total volumes. Typical run times on a single processor workstation to obtain actual total deposition results at comparable accuracy are 200 times less than that for an idealized whole-lung geometry (i.e., a 3D–1D model with airways up to 23rd generation in single-path only).
A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model
Manuscript received November 9, 2014; final manuscript received June 23, 2015; published online July 14, 2015. Assoc. Editor: Naomi Chesler.
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Vaish, M., and Kleinstreuer, C. (September 1, 2015). "A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model." ASME. J Biomech Eng. September 2015; 137(9): 094502. https://doi.org/10.1115/1.4030977
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