In this paper, we discuss some of the primary experimental factors that should be considered when interpreting and implementing the published results of skin electroporation studies concerning measurements of mass transport across the stratum corneum (SC) in the Franz cell. It is explained that the pulse magnitude should always be considered in the context of pulse shape and that transport measurements should always be presented in the context of the trans-SC potential difference (instead of the voltage between the electrodes). The condition of the SC prior to the application of the long-duration pulse strongly influences the evolution of the local transport region (LTR). This is quantified in a simple analytical investigation of the conditions that affect the thermodynamic response of the skin.
Experimental Factors to Be Considered in Electroporation-Mediated Transdermal Diffusion Experiments
Manuscript received July 17, 2015; final manuscript received September 20, 2015; published online October 27, 2015. Assoc. Editor: Ram Devireddy.
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Pavšelj, N., Zorec, B., Miklavčič, D., and Becker, S. (October 27, 2015). "Experimental Factors to Be Considered in Electroporation-Mediated Transdermal Diffusion Experiments." ASME. J Biomech Eng. December 2015; 137(12): 124501. https://doi.org/10.1115/1.4031767
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