This study investigated the effects of intraspecimen variations in tissue mineral density (TMD) on the apparent-level stiffness of human trabecular bone. High-resolution finite element (FE) models were created for each of 12 human trabecular bone specimens, using both microcomputed tomography (μCT) and “gold-standard” synchrotron radiation μCT (SRμCT) data. Our results confirm that incorporating TMD spatial variation reduces the calculated apparent stiffness compared to homogeneous TMD models. This effect exists for both μCT- and SRμCT-based FE models, but is exaggerated in μCT-based models. This study provides a direct comparison of μCT to SRμCT data and is thereby able to conclude that the influence of including TMD heterogeneity is overestimated in μCT-based models.
Effect of Intraspecimen Spatial Variation in Tissue Mineral Density on the Apparent Stiffness of Trabecular Bone
Manuscript received August 5, 2014; final manuscript received November 17, 2014; accepted manuscript posted December 10, 2014; published online December 10, 2014. Assoc. Editor: Blaine A. Christiansen.
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Kaynia, N., Soohoo, E., Keaveny, T. M., and Kazakia, G. J. (January 1, 2015). "Effect of Intraspecimen Spatial Variation in Tissue Mineral Density on the Apparent Stiffness of Trabecular Bone." ASME. J Biomech Eng. January 2015; 137(1): 011010. https://doi.org/10.1115/1.4029178
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