Post-traumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen.
Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model
Manuscript received September 10, 2013; final manuscript received April 6, 2014; accepted manuscript posted April 22, 2014; published online May 12, 2014. Assoc. Editor: Kristen Billiar.
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Fischenich, K. M., Coatney, G. A., Haverkamp, J. H., Button, K. D., DeCamp, C., Haut, R. C., and Haut Donahue, T. L. (May 12, 2014). "Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model." ASME. J Biomech Eng. July 2014; 136(7): 071001. https://doi.org/10.1115/1.4027468
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