Three-dimensional numerical simulations are employed to investigate the hemodynamic effects of abnormal E/A ratios on left ventricular filling. The simulations are performed in a simplified geometric model of the left ventricle (LV) in conjunction with a specified endocardial motion. The model has been carefully designed to match the important geometric and flow parameters under the physiological conditions. A wide range of E/A ratios from 0 to infinity is employed with the aim to cover all the possible stages of left ventricle diastolic dysfunction (DD). The effects of abnormal E/A ratios on vortex dynamics, flow propagation velocity, energy consumption as well as flow transport and mixing are extensively discussed. Our results are able to confirm some common findings reported by the previous studies, and also uncover some interesting new features.

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