Mouse models are an important way for exploring relationships between blood hemodynamics and eventual plaque formation. We have developed a mouse model of aortic regurgitation (AR) that produces large changes in plaque burden with charges in hemodynamics [Zhou et al., 2010, "Aortic Regurgitation Dramatically Alters the Distribution of Atherosclerotic Lesions and Enhances Atherogenesis in Mice," Arterioscler. Thromb. Vasc. Biol., 30(6), pp. 1181–1188]. In this paper, we explore the amount of detail needed for realistic computational fluid dynamics (CFD) calculations in this experimental model. The CFD calculations use inputs based on experimental measurements from ultrasound (US), micro computed tomography (CT), and both anatomical magnetic resonance imaging (MRI) and phase contrast MRI (PC-MRI). The adequacy of five different levels of model complexity (a) subject-specific CT data from a single mouse; (b) subject-specific CT centerlines with radii from US; (c) same as (b) but with MRI derived centerlines; (d) average CT centerlines and averaged vessel radius and branching vessels; and (e) same as (d) but with averaged MRI centerlines) is evaluated by demonstrating their impact on relative residence time (RRT) outputs. The paper concludes by demonstrating the necessity of subject-specific geometry and recommends for inputs the use of CT or anatomical MRI for establishing the aortic centerlines, M-mode US for scaling the aortic diameters, and a combination of PC-MRI and Doppler US for estimating the spatial and temporal characteristics of the input wave forms.
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October 2014
Research-Article
Inputs for Subject-Specific Computational Fluid Dynamics Simulation of Blood Flow in the Mouse Aorta
Mark Van Doormaal,
Mark Van Doormaal
Mouse Imaging Centre,
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
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Yu-Qing Zhou,
Yu-Qing Zhou
Mouse Imaging Centre,
e-mail: yqzhou@mouseimaging.ca
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
e-mail: yqzhou@mouseimaging.ca
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Xiaoli Zhang,
Xiaoli Zhang
Mouse Imaging Centre,
e-mail: xzhang@mouseimaging.ca
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
e-mail: xzhang@mouseimaging.ca
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David A. Steinman,
David A. Steinman
Mechanic and Industrial Engineering,
e-mail: steinman@mie.utoronto.ca
University of Toronto
,5 King's College Road
,Toronto, ON M5S 3G8
, Canada
e-mail: steinman@mie.utoronto.ca
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R. Mark Henkelman
R. Mark Henkelman
1
Mem. ASME
Mouse Imaging Centre,
e-mail: mhenkel@mouseimaging.ca
Mouse Imaging Centre,
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
e-mail: mhenkel@mouseimaging.ca
1Corresponding author.
Search for other works by this author on:
Mark Van Doormaal
Mouse Imaging Centre,
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
Yu-Qing Zhou
Mouse Imaging Centre,
e-mail: yqzhou@mouseimaging.ca
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
e-mail: yqzhou@mouseimaging.ca
Xiaoli Zhang
Mouse Imaging Centre,
e-mail: xzhang@mouseimaging.ca
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
e-mail: xzhang@mouseimaging.ca
David A. Steinman
Mechanic and Industrial Engineering,
e-mail: steinman@mie.utoronto.ca
University of Toronto
,5 King's College Road
,Toronto, ON M5S 3G8
, Canada
e-mail: steinman@mie.utoronto.ca
R. Mark Henkelman
Mem. ASME
Mouse Imaging Centre,
e-mail: mhenkel@mouseimaging.ca
Mouse Imaging Centre,
Hospital for Sick Children
,25 Orde Street
,Toronto, ON M5T 3H7
, Canada
e-mail: mhenkel@mouseimaging.ca
1Corresponding author.
Manuscript received November 15, 2013; final manuscript received July 18, 2014; accepted manuscript posted July 30, 2014; published online August 12, 2014. Assoc. Editor: Alison Marsden.
J Biomech Eng. Oct 2014, 136(10): 101008 (8 pages)
Published Online: August 12, 2014
Article history
Received:
November 15, 2013
Revision Received:
July 18, 2014
Accepted:
July 30, 2014
Citation
Van Doormaal, M., Zhou, Y., Zhang, X., Steinman, D. A., and Mark Henkelman, R. (August 12, 2014). "Inputs for Subject-Specific Computational Fluid Dynamics Simulation of Blood Flow in the Mouse Aorta." ASME. J Biomech Eng. October 2014; 136(10): 101008. https://doi.org/10.1115/1.4028104
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