Drug-resistant hypertensive patients may be treated by mechanical stimulation of stretch-sensitive baroreceptors located in the sinus of carotid arteries. To evaluate the efficacy of endovascular devices to stretch the carotid sinus such that the induced strain might trigger baroreceptors to increase action potential firing rate and thereby reduce systemic blood pressure, numerical simulations were conducted of devices deployed in subject-specific carotid models. Two models were chosen—a typical physiologic carotid and a diminutive atypical physiologic model representing a clinically worst case scenario—to evaluate the effects of device deployment in normal and extreme cases, respectively. Based on the anatomical dimensions of the carotids, two different device sizes were chosen out of five total device sizes available. A fluid structure interaction (FSI) simulation methodology with contact surface between the device and the arterial wall was implemented for resolving the stresses and strains induced by device deployment. Results indicate that device deployment in the carotid sinus of the physiologic model induces an increase of 2.5% and 7.5% in circumferential and longitudinal wall stretch, respectively, and a maximum of 54% increase in von Mises arterial stress at the sinus wall baroreceptor region. The second device, deployed in the diminutive carotid model, induces an increase of 6% in both circumferential and longitudinal stretch and a 50% maximum increase in von Mises stress at the sinus wall baroreceptor region. Device deployment has a minimal effect on blood-flow patterns, indicating that it does not adversely affect carotid bifurcation hemodynamics in the physiologic model. In the smaller carotid model, deployment of the device lowers wall shear stress at sinus by 16% while accelerating flow entering the external carotid artery branch. Our FSI simulations of carotid arteries with deployed device show that the device induces localized increase in wall stretch at the sinus, suggesting that this will activate baroreceptors and subsequently may control hypertension in drug-resistant hypertensive patients, with no consequential deleterious effects on the carotid sinus hemodynamics.
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e-mail: danny.bluestein@sunysb.edu
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April 2012
Research Papers
Fluid Structure Interaction With Contact Surface Methodology for Evaluation of Endovascular Carotid Implants for Drug-Resistant Hypertension Treatment
Dinesh A. Peter,
Dinesh A. Peter
Department of Biomedical Engineering,
Stony Brook University
, Stony Brook, NY 11794
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Yared Alemu,
Yared Alemu
Department of Biomedical Engineering,
Stony Brook University
, Stony Brook, NY 11794
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Michalis Xenos,
Michalis Xenos
Department of Biomedical Engineering,
Stony Brook University
, Stony Brook, NY 11794
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Ori Weisberg,
Ori Weisberg
Vascular Dynamics Ltd.
, Herzelia, Israel
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Itzhak Avneri,
Itzhak Avneri
Vascular Dynamics Ltd.
, Herzelia, Israel
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Moshe Eshkol,
Moshe Eshkol
Vascular Dynamics Ltd.
, Herzelia, Israel
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Tal Oren,
Tal Oren
Vascular Dynamics Ltd.
, Herzelia, Israel
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Moshe Elazar,
Moshe Elazar
Vascular Dynamics Ltd.
, Herzelia, Israel
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Yaron Assaf,
Yaron Assaf
Vascular Dynamics Ltd.
, Herzelia, Israel
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Danny Bluestein
Danny Bluestein
Department of Biomedical Engineering,
e-mail: danny.bluestein@sunysb.edu
Stony Brook University
, Stony Brook, NY 11794
Search for other works by this author on:
Dinesh A. Peter
Department of Biomedical Engineering,
Stony Brook University
, Stony Brook, NY 11794
Yared Alemu
Department of Biomedical Engineering,
Stony Brook University
, Stony Brook, NY 11794
Michalis Xenos
Department of Biomedical Engineering,
Stony Brook University
, Stony Brook, NY 11794
Ori Weisberg
Vascular Dynamics Ltd.
, Herzelia, Israel
Itzhak Avneri
Vascular Dynamics Ltd.
, Herzelia, Israel
Moshe Eshkol
Vascular Dynamics Ltd.
, Herzelia, Israel
Tal Oren
Vascular Dynamics Ltd.
, Herzelia, Israel
Moshe Elazar
Vascular Dynamics Ltd.
, Herzelia, Israel
Yaron Assaf
Vascular Dynamics Ltd.
, Herzelia, Israel
Danny Bluestein
Department of Biomedical Engineering,
Stony Brook University
, Stony Brook, NY 11794e-mail: danny.bluestein@sunysb.edu
J Biomech Eng. Apr 2012, 134(4): 041001 (10 pages)
Published Online: April 12, 2012
Article history
Received:
August 31, 2011
Revised:
February 23, 2012
Posted:
March 14, 2012
Published:
April 9, 2012
Online:
April 12, 2012
Citation
Peter, D. A., Alemu, Y., Xenos, M., Weisberg, O., Avneri, I., Eshkol, M., Oren, T., Elazar, M., Assaf, Y., and Bluestein, D. (April 12, 2012). "Fluid Structure Interaction With Contact Surface Methodology for Evaluation of Endovascular Carotid Implants for Drug-Resistant Hypertension Treatment." ASME. J Biomech Eng. April 2012; 134(4): 041001. https://doi.org/10.1115/1.4006339
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