Determining arterial mechanical properties is important for understanding the work done by the heart and how it changes with cardiovascular disease. Ex vivo tests are necessary to apply various loads to the artery and obtain data to model and predict the behavior under any load. Most ex vivo tests are performed within 24 h of dissection, so the tissue is still “alive.” For large elastic arteries; however, the passive mechanical behavior is attributed mostly to the very stable proteins, elastin, and collagen. If the testing equipment fails, is in use, or is located at another facility, it would be useful to store the vessels and postpone the tests until the equipment is available. The goal of this study is to determine the effects of storage time on the mechanical behavior of the common carotid artery from adult mice. Each artery was tested after storage for 1–28 days in physiologic saline at 4°C. There were no significant effects of storage time on the arterial diameter or force at each pressure, but there were significant effects on the stretch ratio and stress at each pressure. The significant effects on the stretch ratio and stress were due to decreases in the unloaded dimensions with storage time, when measured from cut arterial rings. When the unloaded dimensions were measured instead from histology sections, there were no significant changes with storage time. We conclude that histology sections yield a more consistent measurement of the unloaded dimensions and that there are no significant changes in the mechanical behavior of mouse carotid artery with storage up to 28 days.
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e-mail: mamin2@slu.edu
e-mail: amber.g.kunkel@rice.edu
e-mail: vle2@slu.edu
e-mail: jwagense@slu.edu
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July 2011
Research Papers
Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery
Mazyar Amin,
Mazyar Amin
Department of Biomedical Engineering,
e-mail: mamin2@slu.edu
St. Louis University
, 3507 Lindell Blvd., St. Louis, MO 63103
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Amber G. Kunkel,
Amber G. Kunkel
Department of Computational and Applied Math
e-mail: amber.g.kunkel@rice.edu
Rice University
, 6350 Main St., Houston, TX 77005
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Victoria P. Le,
Victoria P. Le
Department of Biomedical Engineering,
e-mail: vle2@slu.edu
St. Louis University
, 3507 Lindell Blvd., St. Louis, MO 63103
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Jessica E. Wagenseil
Jessica E. Wagenseil
Department of Biomedical Engineering,
e-mail: jwagense@slu.edu
St. Louis University
, 3507 Lindell Blvd., St. Louis, MO 63103
Search for other works by this author on:
Mazyar Amin
Department of Biomedical Engineering,
St. Louis University
, 3507 Lindell Blvd., St. Louis, MO 63103e-mail: mamin2@slu.edu
Amber G. Kunkel
Department of Computational and Applied Math
Rice University
, 6350 Main St., Houston, TX 77005e-mail: amber.g.kunkel@rice.edu
Victoria P. Le
Department of Biomedical Engineering,
St. Louis University
, 3507 Lindell Blvd., St. Louis, MO 63103e-mail: vle2@slu.edu
Jessica E. Wagenseil
Department of Biomedical Engineering,
St. Louis University
, 3507 Lindell Blvd., St. Louis, MO 63103e-mail: jwagense@slu.edu
J Biomech Eng. Jul 2011, 133(7): 071007 (6 pages)
Published Online: July 18, 2011
Article history
Received:
April 14, 2011
Revised:
May 27, 2011
Accepted:
May 27, 2011
Online:
July 18, 2011
Published:
July 18, 2011
Citation
Amin, M., Kunkel, A. G., Le, V. P., and Wagenseil, J. E. (July 18, 2011). "Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery." ASME. J Biomech Eng. July 2011; 133(7): 071007. https://doi.org/10.1115/1.4004415
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