Oxygen is essential to maintaining normal brain function. A large body of evidence suggests that the partial pressure of oxygen in brain tissue is physiologically maintained within a narrow range in accordance with region-specific brain activity. Since the transportation of oxygen in the brain tissue is mainly driven by a diffusion process caused by a concentration gradient of oxygen from blood to cells, the spatial organization of the vascular system, in which the oxygen content is higher than in tissue, is a key factor for maintaining effective transportation. In addition, a local mechanism that controls energy demand and blood flow supply plays a critical role in moment-to-moment adjustment of tissue in response to dynamically varying brain activity. In this review, we discuss the spatiotemporal structures of brain tissue oxygen transport in relation to local brain activity based on recent reports of tissue measurements with polarographic oxygen microsensors in combination with simultaneous recordings of neural activity and local cerebral blood flow in anesthetized animal models. Although a physiological mechanism of oxygen level sensing and control of oxygen transport remains largely unknown, theoretical models of oxygen transport are a powerful tool for better understanding the short-term and long-term effects of local changes in oxygen demand and supply. Finally, emerging new techniques for three-dimensional imaging of the spatiotemporal dynamics of map may enable us to provide a whole picture of how the physiological system controls the balance between demand and supply of oxygen during both normal and pathological brain activity.
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e-mail: masamoto@mce.uec.ac.jp
e-mail: tanishita@sd.keio.ac.jp
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July 2009
Technology Review
Oxygen Transport in Brain Tissue
Kazuto Masamoto,
Kazuto Masamoto
Education and Research Center for Frontier Science and Engineering,
e-mail: masamoto@mce.uec.ac.jp
University of Electro-Communications
, 1-5-1 Chofugaoka, Chofu-shi, Tokyo 182-8585, Japan
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Kazuo Tanishita
Kazuo Tanishita
Department of System Design Engineering,
e-mail: tanishita@sd.keio.ac.jp
Keio University
, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
Search for other works by this author on:
Kazuto Masamoto
Education and Research Center for Frontier Science and Engineering,
University of Electro-Communications
, 1-5-1 Chofugaoka, Chofu-shi, Tokyo 182-8585, Japane-mail: masamoto@mce.uec.ac.jp
Kazuo Tanishita
Department of System Design Engineering,
Keio University
, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japane-mail: tanishita@sd.keio.ac.jp
J Biomech Eng. Jul 2009, 131(7): 074002 (6 pages)
Published Online: July 27, 2009
Article history
Received:
June 23, 2009
Revised:
June 29, 2009
Published:
July 27, 2009
Citation
Masamoto, K., and Tanishita, K. (July 27, 2009). "Oxygen Transport in Brain Tissue." ASME. J Biomech Eng. July 2009; 131(7): 074002. https://doi.org/10.1115/1.3184694
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