Atherosclerotic plaques are distributed differently in the aortic arches of C57BL/6 (B6) and 129/SvEv (129) apolipoprotein E (apoE)-deficient mice. It is now recognized that hemodynamic wall shear stress (WSS) plays an important role in the localization of atherosclerotic development. Since the blood flow field in the vessel is modulated by the vascular geometry, we quantitatively examined the difference in the aortic arch geometry and hemodynamic WSS between the two corresponding wild-type mouse strains. The three-dimensional (3D) geometry of 14 murine aortic arches, seven from each strain, was characterized using casts and stereo microscopic imaging. Based on the geometry of each cast, an average 3D geometry of the aortic arch for each mouse strain was obtained, and computational fluid dynamic calculations were performed in the two average aortic arches. Many geometric features, including aortic arch shape, vessel diameter, and branch locations, were significantly different at between the two mouse strains. Lower shear stress was found at the inner curvature of the aortic arch in the 129 strain, corresponding to greater involvement in the corresponding apoE-deficient mice relative to the B6 strain. These results support the notion that heritable features of arterial geometry can contribute to individual differences in local susceptibility to arterial disease.
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e-mail: mort.friedman@duke.edu
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December 2009
Research Papers
Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice
Ji Zhang,
Ji Zhang
Department of Biomedical Engineering,
Duke University
, Durham, NC 27708-0281
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Jessica Shih,
Jessica Shih
Department of Biomedical Engineering,
Duke University
, Durham, NC 27708-0281
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Federico Lopez-Bertoni,
Federico Lopez-Bertoni
Department of Biomedical Engineering,
Duke University
, Durham, NC 27708-0281
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John R. Hagaman,
John R. Hagaman
Department of Pathology and Laboratory Medicine,
University of North Carolina at Chapel Hill
, Chapel Hill, NC 27599-7525
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Nobuyo Maeda,
Nobuyo Maeda
Department of Pathology and Laboratory Medicine,
University of North Carolina at Chapel Hill
, Chapel Hill, NC 27599-7525
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Morton H. Friedman
Morton H. Friedman
Department of Biomedical Engineering,
e-mail: mort.friedman@duke.edu
Duke University
, Durham, NC 27708-0281
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Hui Zhu
Ji Zhang
Department of Biomedical Engineering,
Duke University
, Durham, NC 27708-0281
Jessica Shih
Department of Biomedical Engineering,
Duke University
, Durham, NC 27708-0281
Federico Lopez-Bertoni
Department of Biomedical Engineering,
Duke University
, Durham, NC 27708-0281
John R. Hagaman
Department of Pathology and Laboratory Medicine,
University of North Carolina at Chapel Hill
, Chapel Hill, NC 27599-7525
Nobuyo Maeda
Department of Pathology and Laboratory Medicine,
University of North Carolina at Chapel Hill
, Chapel Hill, NC 27599-7525
Morton H. Friedman
Department of Biomedical Engineering,
Duke University
, Durham, NC 27708-0281e-mail: mort.friedman@duke.edu
J Biomech Eng. Dec 2009, 131(12): 121005 (7 pages)
Published Online: November 4, 2009
Article history
Received:
May 13, 2009
Revised:
July 16, 2009
Posted:
September 4, 2009
Published:
November 4, 2009
Online:
November 4, 2009
Citation
Zhu, H., Zhang, J., Shih, J., Lopez-Bertoni, F., Hagaman, J. R., Maeda, N., and Friedman, M. H. (November 4, 2009). "Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice." ASME. J Biomech Eng. December 2009; 131(12): 121005. https://doi.org/10.1115/1.4000168
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