Cartilage morphology change is an important biomarker for the progression of osteoarthritis. The purpose of this study was to assess the accuracy of in vivo cartilage thickness measurements from MR image-based 3D cartilage models using a laser scanning method and to test if the accuracy changes with cartilage thickness. Three-dimensional tibial cartilage models were created from MR images (in-plane resolution of 0.55 mm and thickness of 1.5 mm) of osteoarthritic knees of ten patients prior to total knee replacement surgery using a semi-automated B-spline segmentation algorithm. Following surgery, the resected tibial plateaus were laser scanned and made into 3D models. The MR image and laser-scan based models were registered to each other using a shape matching technique. The thicknesses were compared point wise for the overall surface. The linear mixed-effects model was used for statistical test. On average, taking account of individual variations, the thickness measurements in MRI were overestimated in thinner regions. The cartilage thicker than 2.5 mm was accurately predicted in MRI, though the thick cartilage in the central regions was underestimated. The accuracy of thickness measurements in the MRI-derived cartilage models systemically varied according to native cartilage thickness.
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December 2009
Research Papers
Accuracy of 3D Cartilage Models Generated From MR Images Is Dependent on Cartilage Thickness: Laser Scanner Based Validation of In Vivo Cartilage
Seungbum Koo, PhD,
Seungbum Koo, PhD
School of Mechanical Engineering,
e-mail: skoo@cau.ac.kr
Chung-Ang University
, Seoul 156-756, South Korea
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Nicholas J. Giori, MD,
Nicholas J. Giori, MD
Department of Orthopedic Surgery,
Stanford University
, 450 Broadway Street, Pavilion C, 4th Floor Redwood City, CA 94063-6342; VA Palo Alto Healthcare System
, 3801 Miranda Avenue, Palo Alto, CA 94304-1290
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Garry E. Gold, MD,
Garry E. Gold, MD
Department of Radiology,
Stanford University
, Stanford, CA 94305
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Chris O. Dyrby,
Chris O. Dyrby
Engineer
VA Palo Alto Healthcare System
, 3801 Miranda Avenue, Palo Alto, CA 94304-1290; Department of Mechanical Engineering, Stanford University
, 496 Lomita Mall, Durand Building, Room 061, Stanford, CA 94305-4038
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Thomas P. Andriacchi, PhD
Thomas P. Andriacchi, PhD
Department of Orthopedic Surgery,
Stanford University
, 450 Broadway Street, Pavilion C, 4th Floor, Redwood City, CA 94063-6342; VA Palo Alto Healthcare System
, 3801 Miranda Avenue, Palo Alto, CA 94304-1290; Department of Mechanical Engineering, Stanford University
, 496 Lomita Mall, Durand Building, Room 061, Stanford, CA 94305-4038
Search for other works by this author on:
Seungbum Koo, PhD
School of Mechanical Engineering,
Chung-Ang University
, Seoul 156-756, South Koreae-mail: skoo@cau.ac.kr
Nicholas J. Giori, MD
Department of Orthopedic Surgery,
Stanford University
, 450 Broadway Street, Pavilion C, 4th Floor Redwood City, CA 94063-6342; VA Palo Alto Healthcare System
, 3801 Miranda Avenue, Palo Alto, CA 94304-1290
Garry E. Gold, MD
Department of Radiology,
Stanford University
, Stanford, CA 94305
Chris O. Dyrby
Engineer
VA Palo Alto Healthcare System
, 3801 Miranda Avenue, Palo Alto, CA 94304-1290; Department of Mechanical Engineering, Stanford University
, 496 Lomita Mall, Durand Building, Room 061, Stanford, CA 94305-4038
Thomas P. Andriacchi, PhD
Department of Orthopedic Surgery,
Stanford University
, 450 Broadway Street, Pavilion C, 4th Floor, Redwood City, CA 94063-6342; VA Palo Alto Healthcare System
, 3801 Miranda Avenue, Palo Alto, CA 94304-1290; Department of Mechanical Engineering, Stanford University
, 496 Lomita Mall, Durand Building, Room 061, Stanford, CA 94305-4038J Biomech Eng. Dec 2009, 131(12): 121004 (5 pages)
Published Online: October 29, 2009
Article history
Received:
December 31, 2007
Revised:
June 3, 2009
Posted:
September 1, 2009
Published:
October 29, 2009
Citation
Koo, S., Giori, N. J., Gold, G. E., Dyrby, C. O., and Andriacchi, T. P. (October 29, 2009). "Accuracy of 3D Cartilage Models Generated From MR Images Is Dependent on Cartilage Thickness: Laser Scanner Based Validation of In Vivo Cartilage." ASME. J Biomech Eng. December 2009; 131(12): 121004. https://doi.org/10.1115/1.4000087
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