This work deals with the study of the analytical relations between porosity of cancellous bone and its mechanical properties. The Stieltjes representation of the effective shear complex modulus of cancellous bone is exploited to recover porosity. The microstructural information is contained in the spectral measure in this analytical representation. The spectral function can be recovered from the effective measurements over a range of frequencies. The problem of reconstruction of the spectral measure is very ill-posed. Regularized algorithm is derived to ensure stability of the results. The proposed method does not use any specific assumptions about the microgeometry of bone. The approach does not rely on correlation analysis, it uses analytical relationships. For validation purposes, complex shear modulus over a range of frequencies was calculated by the finite element method using micro-computed tomography (micro-CT) images of human cancellous bone. The calculated values were used in numerical algorithm to recover bone porosity. At the microlevel, bone was modeled as a heterogeneous medium composed of trabeculae tissue and bone marrow treated as transversely isotropic elastic and isotropic viscoelastic materials, respectively. Recovered porosity values are in excellent agreement with true porosity found from the corresponding micro-CT images.
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e-mail: cb28@utah.edu
e-mail: elena@math.utah.edu
e-mail: yeni@bjc.hfh.edu
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December 2009
Research Papers
Analytical Approach to Recovering Bone Porosity From Effective Complex Shear Modulus
Carlos Bonifasi-Lista,
Carlos Bonifasi-Lista
Department of Bioengineering,
e-mail: cb28@utah.edu
University of Utah
, 72 South Central Campus Drive, Room 2646, Salt Lake City, UT 84112
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Elena Cherkaev,
Elena Cherkaev
Department of Mathematics,
e-mail: elena@math.utah.edu
University of Utah
, 155 South 1400 East, JWB 233, Salt Lake City, UT 84112
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Yener N. Yeni
Yener N. Yeni
Bone and Joint Center,
e-mail: yeni@bjc.hfh.edu
Henry Ford Hospital
, 2799 West Grand Boulevard, Detroit, MI 48202
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Carlos Bonifasi-Lista
Department of Bioengineering,
University of Utah
, 72 South Central Campus Drive, Room 2646, Salt Lake City, UT 84112e-mail: cb28@utah.edu
Elena Cherkaev
Department of Mathematics,
University of Utah
, 155 South 1400 East, JWB 233, Salt Lake City, UT 84112e-mail: elena@math.utah.edu
Yener N. Yeni
Bone and Joint Center,
Henry Ford Hospital
, 2799 West Grand Boulevard, Detroit, MI 48202e-mail: yeni@bjc.hfh.edu
J Biomech Eng. Dec 2009, 131(12): 121003 (8 pages)
Published Online: October 29, 2009
Article history
Received:
January 20, 2009
Revised:
May 14, 2009
Posted:
September 1, 2009
Published:
October 29, 2009
Citation
Bonifasi-Lista, C., Cherkaev, E., and Yeni, Y. N. (October 29, 2009). "Analytical Approach to Recovering Bone Porosity From Effective Complex Shear Modulus." ASME. J Biomech Eng. December 2009; 131(12): 121003. https://doi.org/10.1115/1.4000082
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