Traditionally, the complex mechanical behavior of planar soft biological tissues is characterized by (multi)axial tensile testing. While uniaxial tests do not provide sufficient information for a full characterization of the material anisotropy, biaxial tensile tests are difficult to perform and tethering effects limit the analyses to a small central portion of the test sample. In both cases, determination of local mechanical properties is not trivial. Local mechanical characterization may be performed by indentation testing. Conventional indentation tests, however, often assume linear elastic and isotropic material properties, and therefore these tests are of limited use in characterizing the nonlinear, anisotropic material behavior typical for planar soft biological tissues. In this study, a spherical indentation experiment assuming large deformations is proposed. A finite element model of the aortic valve leaflet demonstrates that combining force and deformation gradient data, one single indentation test provides sufficient information to characterize the local material behavior. Parameter estimation is used to fit the computational model to simulated experimental data. The aortic valve leaflet is chosen as a typical example. However, the proposed method is expected to apply for the mechanical characterization of planar soft biological materials in general.
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June 2006
Technical Papers
Mechanical Characterization of Anisotropic Planar Biological Soft Tissues Using Large Indentation: A Computational Feasibility Study
Martijn A. J. Cox
,
Martijn A. J. Cox
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The Netherlands
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Niels J. B. Driessen
,
Niels J. B. Driessen
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The Netherlands
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Carlijn V. C. Bouten
,
Carlijn V. C. Bouten
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The Netherlands
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Frank P. T. Baaijens
Frank P. T. Baaijens
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The Netherlands
Search for other works by this author on:
Martijn A. J. Cox
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The Netherlands
Niels J. B. Driessen
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The Netherlands
Carlijn V. C. Bouten
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The Netherlands
Frank P. T. Baaijens
Department of Biomedical Engineering,
Eindhoven University of Technology
, PO Box 513, 5600 MB Eindhoven, The NetherlandsJ Biomech Eng. Jun 2006, 128(3): 428-436 (9 pages)
Published Online: October 27, 2005
Article history
Received:
May 13, 2005
Revised:
October 27, 2005
Citation
Cox, M. A. J., Driessen, N. J. B., Bouten, C. V. C., and Baaijens, F. P. T. (October 27, 2005). "Mechanical Characterization of Anisotropic Planar Biological Soft Tissues Using Large Indentation: A Computational Feasibility Study." ASME. J Biomech Eng. June 2006; 128(3): 428–436. https://doi.org/10.1115/1.2187040
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