Coronary artery disease (CAD) is characterized by the progression of atherosclerosis, a complex pathological process involving the initiation, deposition, development, and breakdown of the plaque. The blood flow mechanics in arteries play a critical role in the targeted locations and progression of atherosclerotic plaque. In coronary arteries with motion during the cardiac contraction and relaxation, the hemodynamic flow field is substantially different from the other arterial sites with predilection of atherosclerosis. In this study, our efforts focused on the effects of arterial motion and local geometry on the hemodynamics of a left anterior descending (LAD) coronary artery before and after clinical intervention to treat the disease. Three-dimensional (3D) arterial segments were reconstructed at 10 phases of the cardiac cycle for both pre- and postintervention based on the fusion of intravascular ultrasound (IVUS) and biplane angiographic images. An arbitrary Lagrangian-Eulerian formulation was used for the computational fluid dynamic analysis. The measured arterial translation was observed to be larger during systole after intervention and more out-of-plane motion was observed before intervention, indicating substantial alterations in the cardiac contraction after angioplasty. The time averaged axial wall shear stress ranged from before intervention compared to after intervention. Substantial oscillatory shear stress was present in the preintervention flow dynamics compared to that in the postintervention case.
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e-mail: Chandran@engineering.uiowa.edu
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February 2006
Technical Papers
Comparison of Left Anterior Descending Coronary Artery Hemodynamics Before and After Angioplasty
S. D. Ramaswamy,
S. D. Ramaswamy
Department of Biomedical Engineering,
University of Iowa
, Iowa City, Iowa 52242
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S. C. Vigmostad,
S. C. Vigmostad
Department of Biomedical Engineering,
University of Iowa
, Iowa City, Iowa 52242
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A. Wahle,
A. Wahle
Department of Electrical and Computer Engineering,
University of Iowa
, Iowa City, Iowa 52242
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Y.-G. Lai,
Y.-G. Lai
IIHR-Hydroscience and Engineering,
University of Iowa
, Iowa City, Iowa 52242
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M. E. Olszewski,
M. E. Olszewski
Department of Electrical and Computer Engineering,
University of Iowa
, Iowa City, Iowa 52242
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K. C. Braddy,
K. C. Braddy
Department of Internal Medicine,
University of Iowa
, Iowa City, Iowa 52242
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T. M. H. Brennan,
T. M. H. Brennan
Department of Internal Medicine,
University of Iowa
, Iowa City, Iowa 52242
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J. D. Rossen,
J. D. Rossen
Department of Internal Medicine,
University of Iowa
, Iowa City, Iowa 52242
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M. Sonka,
M. Sonka
Department of Electrical and Computer Engineering,
University of Iowa
, Iowa City, Iowa 52242
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K. B. Chandran
K. B. Chandran
319 335 5640
319 335 5631
Department of Biomedical Engineering and IIHR-Hydroscience and Engineering,
e-mail: Chandran@engineering.uiowa.edu
University of Iowa
, Iowa City, Iowa 52242
Search for other works by this author on:
S. D. Ramaswamy
Department of Biomedical Engineering,
University of Iowa
, Iowa City, Iowa 52242
S. C. Vigmostad
Department of Biomedical Engineering,
University of Iowa
, Iowa City, Iowa 52242
A. Wahle
Department of Electrical and Computer Engineering,
University of Iowa
, Iowa City, Iowa 52242
Y.-G. Lai
IIHR-Hydroscience and Engineering,
University of Iowa
, Iowa City, Iowa 52242
M. E. Olszewski
Department of Electrical and Computer Engineering,
University of Iowa
, Iowa City, Iowa 52242
K. C. Braddy
Department of Internal Medicine,
University of Iowa
, Iowa City, Iowa 52242
T. M. H. Brennan
Department of Internal Medicine,
University of Iowa
, Iowa City, Iowa 52242
J. D. Rossen
Department of Internal Medicine,
University of Iowa
, Iowa City, Iowa 52242
M. Sonka
Department of Electrical and Computer Engineering,
University of Iowa
, Iowa City, Iowa 52242
K. B. Chandran
319 335 5640
319 335 5631
Department of Biomedical Engineering and IIHR-Hydroscience and Engineering,
University of Iowa
, Iowa City, Iowa 52242e-mail: Chandran@engineering.uiowa.edu
J Biomech Eng. Feb 2006, 128(1): 40-48 (9 pages)
Published Online: September 21, 2005
Article history
Received:
February 9, 2005
Revised:
September 21, 2005
Citation
Ramaswamy, S. D., Vigmostad, S. C., Wahle, A., Lai, Y., Olszewski, M. E., Braddy, K. C., Brennan, T. M. H., Rossen, J. D., Sonka, M., and Chandran, K. B. (September 21, 2005). "Comparison of Left Anterior Descending Coronary Artery Hemodynamics Before and After Angioplasty." ASME. J Biomech Eng. February 2006; 128(1): 40–48. https://doi.org/10.1115/1.2132371
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