Interstitial fluid pressurization plays an important role in cartilage biomechanics and is believed to be a primary mechanism of load support in synovial joints. The objective of this study was to investigate the effects of enzymatic degradation on the interstitial fluid load support mechanism of articular cartilage in unconfined compression. Thirty-seven immature bovine cartilage plugs were tested in unconfined compression before and after enzymatic digestion. The peak fluid load support decreased significantly from to and from to after 18-hours digestion with 1.0 u/mg-wet-weight and 0.7 u/mg-wet-weight of collagenase, respectively. Treatment with 0.1 u/ml of chondroitinase ABC for 24 hours also significantly reduced the peak fluid load support from to The drop in interstitial fluid load support following enzymatic treatment is believed to result from a decrease in the ratio of tensile to compressive moduli of the solid matrix.
Cartilage Interstitial Fluid Load Support in Unconfined Compression Following Enzymatic Digestion
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division September 23, 2003; revision received July 26, 2004. Associate Editor: Lori A. Setton.
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Basalo, I. M., Mauck , R. L., Kelly, T. N., Nicoll, S. B., Chen, F. H., Hung, C. T., and Ateshian, G. A. (February 4, 2005). "Cartilage Interstitial Fluid Load Support in Unconfined Compression Following Enzymatic Digestion ." ASME. J Biomech Eng. December 2004; 126(6): 779–786. https://doi.org/10.1115/1.1824123
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