A finite-element approach was formulated, aimed at enabling an integrated study of mechanical and biochemical factors that control the functional development of tissue engineered constructs. A nonlinear biphasic displacement-velocity-pressure description was combined with adjective and diffusive solute transport, uptake and biosynthesis. To illustrate the approach we focused on the synthesis and transport of macromolecules under influence of fluid flow induced by cyclic compression. In order to produce net transport the effect of dispersion was investigated. An abstract representation of biosynthesis was employed, three cases were distinguished: Synthesis dependent on a limited small solute, synthesis dependent on a limited large solute and synthesis independent of solute transport. Results show that a dispersion model can account for augmented solute transport by cyclic compression and indicate the different sensitivity to loading that can be expected depending on the size of the limiting solute.
An Integrated Finite-Element Approach to Mechanics, Transport and Biosynthesis in Tissue Engineering
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division August 1, 2002; revision received August 20, 2003. Associate Editor: L. Setton.
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Sengers , B. G., Oomens , C. W. J., and Baaijens, F. P. T. (March 9, 2004). "An Integrated Finite-Element Approach to Mechanics, Transport and Biosynthesis in Tissue Engineering ." ASME. J Biomech Eng. February 2004; 126(1): 82–91. https://doi.org/10.1115/1.1645526
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