The inner diameter and wall thickness of rat middle cerebral arteries (MCAs) were measured in vitro in both a pressure-induced, myogenically-active state and a drug-induced, passive state to quantify active and passive mechanical behavior. Elasticity parameters from the literature (stiffness derived from an exponential pressure-diameter relationship, β, and elasticity in response to an increment in pressure, and a novel elasticity parameter in response to smooth muscle cell (SMC) activation, were calculated. β for all passive MCAs was 9.11±1.07 but could not be calculated for active vessels. The incremental stiffness increased significantly with pressure in passive vessels; increased from 5.6±0.5 at 75 mmHg to 14.7±2.4 at 125 mmHg, (p<0.05). In active vessels, remained relatively constant (5.5±2.4 at 75 mmHg and 6.2±1.0 at 125 mmHg). increased significantly with pressure (from 15.1±2.3 at 75 mmHg to 49.4±12.6 at 125 mmHg, p<0.001), indicating a greater contribution of SMC activity to vessel wall stiffness at higher pressures.
Mechanical Properties of Rat Middle Cerebral Arteries With and Without Myogenic Tone
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division June 20, 2002; revision received September 2, 2003. Associate Editor: J. Wayne.
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Coulson, R. J., Cipolla , M. J., Vitullo , L., and Chesler, N. C. (March 9, 2004). "Mechanical Properties of Rat Middle Cerebral Arteries With and Without Myogenic Tone ." ASME. J Biomech Eng. February 2004; 126(1): 76–81. https://doi.org/10.1115/1.1645525
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