Mechanical properties of a polyacrylamide gel with reversible DNA crosslinks are presented. In this system, three DNA strands replace traditional chemical crosslinkers. In contrast to thermoset chemically crosslinked polyacrylamide, the new hydrogel is thermoreversible; crosslink dissociation without the addition of heat is also feasible by introducing a specific removal DNA strand. This hydrogel is characterized by a critical crosslink concentration at which gelation occurs. Below the critical point, a characteristic temperature exists at which a transition in viscosity is observed. Both temperature-dependent viscosity and elastic modulus of the material are functions of crosslink density.
Mechanical Properties of a Reversible, DNA-Crosslinked Polyacrylamide Hydrogel
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division September 16, 2002; revision received September 4, 2003. Associate Editor: M. Sacks.
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Lin, D. C., Yurke, B., and Langrana, N. A. (March 9, 2004). "Mechanical Properties of a Reversible, DNA-Crosslinked Polyacrylamide Hydrogel ." ASME. J Biomech Eng. February 2004; 126(1): 104–110. https://doi.org/10.1115/1.1645529
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